ArticleNature ecology & evolution2020
Experimental evidence for effects of sexual selection on condition-dependent mutation rates.
Article in Nature ecology & evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Predicted deleterious mutations reveal the genetic architecture of male reproductive success in a lekking bird.Nature ecology & evolution · 2025Article
- Sex-Specific Dominance of Gene Expression in Seed Beetles.Molecular biology and evolution · 2024Article
- Pesticide exposure triggers sex-specific inter- and transgenerational effects conditioned by past sexual selection.Proceedings. Biological sciences · 2024Article
- Coevolution of longevity and female germline maintenance.Proceedings. Biological sciences · 2024Article
- Parental kinship coefficient but not paternal coloration predicts early offspring growth in lake char.Heredity · 2024Article
- Heat stress reveals a fertility debt owing to postcopulatory sexual selection.Evolution letters · 2024Article
- Quantitative genetics of breeding coloration in sand lizards; genic capture unlikely to maintain additive genetic variance.Heredity · 2023Article
- Increased male investment in sperm competition results in reduced maintenance of gametes.PLoS biology · 2023Article
- Sexual selection for males with beneficial mutations.Scientific reports · 2022Article
- Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity.BMC biology · 2021Article
- Meiosis and beyond - understanding the mechanistic and evolutionary processes shaping the germline genome.Biological reviews of the Cambridge Philosophical Society · 2021Review
- The importance of pre- and postcopulatory sexual selection promoting adaptation to increasing temperatures.Current zoology · 2021Article
- Intraspecific variation in animal mating signals: a test of Mayr's conjecture.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual selection depletes genetic variation but depleted genetic variation limits the efficacy of sexual selection-a long-standing enigma known as the lek paradox. Here we offer a twist to this paradox by showing that sexual selection and the generation of new genetic variation via mutation may be entangled in an evolutionary feedback loop. We induced DNA damage in the germline of male seed beetles evolved under regimes manipulating the opportunity for natural and sexual selection, and quantified de novo mutations in F2-F7 generations by measuring mutation load. Sexually selected males passed on smaller loads, suggesting that selection for male quality not only purges segregating deleterious alleles, but can also reduce the rate at which such alleles originate de novo. However, when engaging in socio-sexual interactions, males evolved exclusively under sexual selection transferred greater loads, suggesting that trade-offs between naturally and sexually selected fitness components can increase mutation rate. These results offer causality to the widely observed male mutation bias and have implications for the maintenance of genetic variation in fitness.
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