Evidence map›Paper›PMID 32203410›Full record

ArticleNature microbiology2020

Bacterial alginate regulators and phage homologs repress CRISPR-Cas immunity.

Adair L Borges, Bardo Castro, Sutharsan Govindarajan, Tina Solvik, Veronica Escalante, Joseph Bondy-Denomy

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Phage susceptibility to a minimal, modular synthetic CRISPR-Cas system inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  5. The H-NS homologues MvaT and MvaU repress CRISPR-Cas inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Correlation ofInternational journal of molecular sciences · 2024
    Article
  14. Review
  15. Mechanisms regulating the CRISPR-Cas systems.Frontiers in microbiology · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Adair L BorgesDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-1477-7908
Bardo CastroDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Sutharsan GovindarajanDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Tina SolvikDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Veronica EscalanteDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Joseph Bondy-DenomyDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA. joseph.bondy-denomy@ucsf.edu.ORCID http://orcid.org/0000-0002-4909-9481
University of California, San Francisco · US

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Discovering New Roles for CRISPR-Cas in Bacterial PathogenesisDP5OD021344 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2015 to 2019
$2.1M
Uncovering the mechanism and role of a widespread anti-CRISPR-Cas9 proteinR01GM127489 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2018 to 2022
$1.7M
NIGMS NIH HHS R01 GM127489NIH HHS DP5 OD021344
6 · The paper itself

Abstract

CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsAlginatesBacteriaBacterial ProteinsBacteriophagesBase SequenceCRISPR-Cas SystemsDNA-Binding ProteinsGene Expression Regulation, BacterialGenes, BacterialGenes, RegulatorImmunityPseudomonas aeruginosaPseudomonas PhagesTranscription FactorsTranscription, GeneticAlginatesBacterial ProteinsDNA-Binding ProteinsTranscription Factors

Identifiers

PMID32203410
PMCPMC7190418
OpenAlexW3012625358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.