Evidence map›Paper›PMID 32203408›Full record

ReviewNature reviews. Endocrinology2020

Young-onset type 2 diabetes mellitus - implications for morbidity and mortality.

Dianna J Magliano, Julian W Sacre, Jessica L Harding, Edward W Gregg, Paul Z Zimmet, Jonathan E Shaw

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
265citing papers in PubMed, 8 pooled it
45.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

265 citing papers in PubMed, 8 syntheses or guidelines pooled it, 466 citations in OpenAlex.

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205 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Dianna J MaglianoBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia. dianna.magliano@baker.edu.au.
Julian W SacreBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Jessica L HardingDivision of Diabetes Translation, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
Edward W GreggFaculty of Medicine, School of Public Health, Imperial College, London, UK.
Paul Z ZimmetMonash University, Department of Diabetes, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-0627-0776
Jonathan E ShawBaker Heart and Diabetes Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-6187-2203
Baker Heart and Diabetes Institute · AUCenters for Disease Control and Prevention · USImperial College London · GBMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating data suggest that type 2 diabetes mellitus (T2DM) in younger people (aged <40 years), referred to as young-onset T2DM, has a more rapid deterioration of β-cell function than is seen in later-onset T2DM. Furthermore, individuals with young-onset T2DM seem to have a higher risk of complications than those with type 1 diabetes mellitus. As the number of younger adults with T2DM increases, young-onset T2DM is predicted to become a more frequent feature of the broader diabetes mellitus population in both developing and developed nations, particularly in certain ethnicities. However, the magnitude of excess risk of premature death and incident complications remains incompletely understood; likewise, the potential reasons for this excess risk are unclear. Here, we review the evidence pertaining to young-onset T2DM and its current and future burden of disease in terms of incidence and prevalence in both developed and developing nations. In addition, we highlight the associations of young-onset T2DM with premature mortality and morbidity.

Indexed as

AdultAge of OnsetCause of DeathDiabetes Mellitus, Type 2HumansMorbidityMortalityMortality, PrematurePrevalenceYoung Adult

Identifiers

PMID32203408
OpenAlexW3012481772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.