Evidence map›Paper›PMID 32203400›Full record

ReviewNature reviews. Gastroenterology & hepatology2020

The multidisciplinary management of rectal cancer.

Deborah S Keller, Mariana Berho, Rodrigo O Perez, Steven D Wexner, Manish Chand

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05671809 (Effects of Different Treatment for Anorectal Function of Patients With Rectal Cancer), which is not on this map. Cited by 219 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
219citing papers in PubMed, 8 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05671809 not yet recruitingnot on this mapstarted 2023, after this paper: background citation

Effects of Different Treatment for Anorectal Function of Patients With Rectal Cancer: a Study Protocol for a Prospective, Observational, Controlled, Multicentre Study

Typeobservational_patient_registrySponsorSixth Affiliated Hospital, Sun Yat-sen UniversityRan2023 to 2026Enrolled402ConditionsRectal CancerArmsNCRT with surgery, or NCT with surgery, or surgery
3 · Its place in the literature

Who cites it

219 citing papers in PubMed, 8 syntheses or guidelines pooled it, 331 citations in OpenAlex.

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159 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Deborah S KellerDepartment of Surgery, New York-Presbyterian, Columbia University Medical Centre, New York, NY, USA.ORCID http://orcid.org/0000-0002-8645-6206
Mariana BerhoDepartment of Pathology and Laboratory Medicine, Cleveland Clinic Florida, Weston, Florida, USA.
Rodrigo O PerezAngelita & Joaquim Institute, São Paulo, Brazil.
Steven D WexnerDepartment of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida, USA.
Manish ChandWellcome EPSRC Centre for Interventional and Surgical Sciences (WEISS); University College London, London, UK. m.chand@ucl.ac.uk.
Cleveland Clinic Florida · USNewYork–Presbyterian Hospital · USWellcome / EPSRC Centre for Interventional and Surgical Sciences · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rectal cancer treatment has evolved during the past 40 years with the use of a standardized surgical technique for tumour resection: total mesorectal excision. A dramatic reduction in local recurrence rates and improved survival outcomes have been achieved as consequences of a better understanding of the surgical oncology of rectal cancer, and the advent of adjuvant and neoadjuvant treatments to compliment surgery have paved the way for a multidisciplinary approach to disease management. Further improvements in imaging techniques and the ability to identify prognostic factors such as tumour regression, extramural venous invasion and threatened margins have introduced the concept of decision-making based on preoperative staging information. Modern treatment strategies are underpinned by accurate high-resolution imaging guiding both neoadjuvant therapy and precision surgery, followed by meticulous pathological scrutiny identifying the important prognostic factors for adjuvant chemotherapy. Included in these strategies are organ-sparing approaches and watch-and-wait strategies in selected patients. These pathways rely on the close working of interlinked disciplines within a multidisciplinary team. Such multidisciplinary forums are becoming standard in the treatment of rectal cancer across the UK, Europe and, more recently, the USA. This Review examines the essential components of modern-day management of rectal cancer through a multidisciplinary team approach, providing information that is essential for any practising colorectal surgeon to guide the best patient care.

Indexed as

HumansLaparoscopyPatient Care TeamProctectomyRectal Neoplasms

Identifiers

PMID32203400
OpenAlexW3012305074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.