Evidence map›Paper›PMID 32203286›Full record

ReviewNature reviews. Cardiology2020

T cell subsets and functions in atherosclerosis.

Ryosuke Saigusa, Holger Winkels, Klaus Ley

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 483 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
483citing papers in PubMed, 1 pooled it
29.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

483 citing papers in PubMed, 1 synthesis or guideline pooled it, 672 citations in OpenAlex.

  1. Pooled it
  2. Multi-omics integration and machine learning identify an ACKR1Clinical and translational medicine · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. CD8Immunity & ageing : I & A · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Genes · 2026
    Article

423 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryosuke SaigusaDivision of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1640-6182
Holger WinkelsDivision of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, USA.
Klaus LeyDivision of Inflammation Biology, La Jolla Institute for Immunology, La Jolla, CA, USA. klaus@lji.org.ORCID http://orcid.org/0000-0001-9339-3672
La Jolla Institute for Immunology · US

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Epsin in Angiogenesis and Vascular RemodelingR01HL093242 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI CHEN, HONG, WANG, DA-ZHI · 2009 to 2021
$7.3M
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
Molecular Regulation of AtherosclerosisR01HL146134 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2019 to 2022
$3.3M
Immunophenotyping for precision medicine for cardiovascular disease in people living with HIVR01HL148094 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KAPLAN, ROBERT C, LEY, KLAUS F. · 2019 to 2022
$3.3M
Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolitesR01HL140976 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KAPLAN, ROBERT C, KNIGHT, ROB · 2018 to 2021
$3.3M
Myeloid cell interactions with T cells in atherosclerosisR01HL115232 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2012 to 2018
$3.2M
Molecular Mechanisms Regulating Endothelial DysfunctionR01HL137229 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SRIVASTAVA, SANJAY · 2017 to 2020
$2.7M
Vaccination with MHC-II restricted ApoB100 peptides to prevent atherosclerosisR01HL121697 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2015 to 2018
$1.8M
NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R01 HL093242NHLBI NIH HHS R01 HL115232NHLBI NIH HHS R01 HL121697NHLBI NIH HHS R01 HL137229NHLBI NIH HHS R01 HL140976NHLBI NIH HHS R01 HL146134NHLBI NIH HHS R01 HL148094NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing and knockout studies in mice, as well as clinical interventional studies and advanced mRNA sequencing techniques, have drawn attention to the role of T cells as critical drivers and modifiers of the pathogenesis of atherosclerosis. CD4

Indexed as

AnimalsAtherosclerosisBiomarkersCytokinesDisease Models, AnimalHumansMiceT-Lymphocyte SubsetsTranslational Research, BiomedicalBiomarkersCytokines

Identifiers

PMID32203286
PMCPMC7872210
OpenAlexW3010741823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.