Evidence map›Paper›PMID 32203192›Full record

ArticleCellular & molecular immunology2021

The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo.

Lei Zhang, Yuanlin Ying, Shuqiu Chen, Preston R Arnold, Fafa Tian, Laurie J Minze, Xiang Xiao, Xian C Li

Open access · bronzeAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Serum Th-2 cytokines and FEVAmerican journal of industrial medicine · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Lei ZhangImmunobiology and Transplant Science Center, and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA.
Yuanlin YingImmunobiology and Transplant Science Center, and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA.
Shuqiu ChenImmunobiology and Transplant Science Center, and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA.
Preston R ArnoldImmunobiology and Transplant Science Center, and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA.
Fafa TianDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Laurie J Minze
Xiang XiaoImmunobiology and Transplant Science Center, and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA.
Xian C LiImmunobiology and Transplant Science Center, and Department of Surgery, Houston Methodist Hospital, Texas Medical Center, Houston, Texas, USA. xcli@houstonmethodist.org.
Houston Methodist · USXiangya Hospital Central South University · CNMethodist Hospital · USTexas Medical Center · USZhongda Hospital Southeast University · CN

Funding

Modulation of innate immune cells to create transplant toleranceR01AI080779 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Xian Chang Li · 2011 to 2026
$5.2M
Modulation of innate immune cells to create transplant toleranceR56AI080779 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LI, XIAN CHANG · 2010 to 2010
$435k
NIAID NIH HHS R01 AI080779NIAID NIH HHS R56 AI080779
6 · The paper itself

Abstract

The exact relationships between group 2 innate lymphoid cells (ILC2s) and Th2 cells in type 2 pathology, as well as the mechanisms that restrain the responses of these cells, remain poorly defined. Here we examined the roles of ILC2s and Th2 cells in type 2 lung pathology in vivo using germline and conditional Relb-deficient mice. We found that mice with germline deletion of Relb (Relb

Indexed as

Immunity, InnateAdoptive TransferAnimalsCytokinesHomeodomain ProteinsLungLymphocytesMiceMice, Inbred C57BLMice, KnockoutRepressor ProteinsTh2 CellsTranscription Factor RelBTumor Suppressor ProteinsBcl11b protein, mouseCytokinesHomeodomain ProteinsRAG-1 proteinRelb protein, mouseRepressor ProteinsTranscription Factor RelBTumor Suppressor ProteinsAllergic inflammationInnate lymphoid cellsNF-κBRelBTh2 cellstype 2 pathology

Identifiers

PMID32203192
PMCPMC7852540
OpenAlexW3012459037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.