ArticleJournal of perinatology : official journal of the California Perinatal Association2020
Can we improve early identification of neonatal late-onset sepsis? A validated prediction model.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Meta-analysis of the role of neutrophil to lymphocyte ratio in neonatal sepsis.BMC infectious diseases · 2023Pooled it
- Comparison of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis.BMC pediatrics · 2023Pooled it
- Accuracy of the neutrophil-to-lymphocyte ratio for the diagnosis of neonatal sepsis: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- The Utility of Peripheral Blood Leucocyte Ratios as Biomarkers in Neonatal Sepsis: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- The Neutrophil-to-Lymphocyte Ratio (NLR) Can Predict Sepsis's Presence and Severity in Malnourished Infants-A Single Center Experience.Children (Basel, Switzerland) · 2023Article
- Evaluation of Haematological Parameters and Uric Acid in the Diagnosis of Late Onset Neonatal Sepsis.Cureus · 2023Article
- Carboxyhemoglobin Levels in Preterm Neonatal Late-Onset Sepsis: to Predict or not to Predict.Mediterranean journal of hematology and infectious diseases · 2023Article
- Artificial and human intelligence for early identification of neonatal sepsis.Pediatric research · 2023Review
- Prediction modelling in the early detection of neonatal sepsis.World journal of pediatrics : WJP · 2022Review
- Antibiotic Discontinuation 24 h After Neonatal Late-Onset Sepsis Work-Up-A Validated Decision Tree Model.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNo single test can accurately identify neonatal late-onset sepsis (LOS). Our aim was to use clinical evaluation with laboratory tests to rapidly assess sepsis risk. STUDY
designA retrospective case-control study was performed in a tertiary Neonatal Center during the years 2016-2019. Infants with bacteriologically confirmed LOS were compared with control infants. A clinical health evaluation score was assigned to each infant. A prediction model was developed and validated by multivariable analysis.
resultsThe study included 145 infants, 48 with sepsis, and 97 controls. LOS was independently associated with: sick appearance (OR: 5.7, 95% CI: 1.1-29.1), C-reactive protein > 0.75 (OR: 5.4, 95% CI: 1.1-26.3), and neutrophil-to-lymphocyte ratio > 1.5 (OR: 6.7, 95% CI: 1.2-38.5). Our model had an area under the receiver operating characteristic curve of 0.92 (95% CI: 0.86-0.97).
conclusionsClinical evaluation with neutrophil-to-lymphocyte ratio and C-reactive protein can rapidly identify LOS enabling decreased health costs and antibiotic use.
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