ArticleMolecular psychiatry2021
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder.
Open access · bronzeAbstract read
In one paragraph
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Pharmacogenomic scores in psychiatry: systematic review of current evidence.Translational psychiatry · 2024Pooled it
- Review and Consensus on Pharmacogenomic Testing in Psychiatry.Pharmacopsychiatry · 2021Pooled it
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Dissecting the polygenic architecture of psychopathology via singular value decomposition of eight psychiatric genome-wide association studies and evaluation of component-based polygenic scores.General psychiatry · 2026Article
- Associations and interaction effects of socioeconomic, lifestyle, and genetic factors on intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Molecular and Neuroimaging Correlates of Bipolar Disorder: Linking Inflammation, Mitochondria, and Brain Circuitry.International journal of molecular sciences · 2026Review
- Lithium Therapeutic Functions: An Update on Pharmacokinetics, Pathophysiological Mechanisms of Action, Toxicity, and Side Effects.Molecular neurobiology · 2026Review
- Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Polygenic Contributions to Lithium Augmentation Outcomes in Unipolar Depression.JAMA psychiatry · 2025Article
- A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Genetics of Response to ECT, TMS, Ketamine and Esketamine.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Review
- Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.Biological psychiatry global open science · 2025Article
- Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.International journal of molecular sciences · 2025Review
- The Mechanisms of Lithium Action: The Old and New Findings.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues.Human genomics · 2025Review
- Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.PloS one · 2025Article
- Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Article
- Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder.ArXiv · 2024Article
- Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal.Psychological medicine · 2024Article
- Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder.Molecular psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
114 authors at 20 institutions in 24 countries.
Azmeraw T Amare *Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-7940-0335
Klaus Oliver Schubert *Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Liping HouIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3972-245X
Scott R ClarkDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Sergi PapiolInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9366-8728
Micah CearnsDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.ORCID http://orcid.org/0000-0002-3353-8566
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-7135-762X
Franziska DegenhardtInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Fasil Tekola-AyeleEpidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Yi-Hsiang HsuHSL Institute for Aging Research, Harvard Medical School, Boston, MA, USA.
Tatyana ShekhtmanDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Mazda AdliDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Nirmala AkulaIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Kazufumi AkiyamaDepartment of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Raffaella ArdauUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Bárbara AriasUnitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain.
Jean-Michel AubryDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Lena BacklundDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Abesh Kumar BhattacharjeeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Frank BellivierINSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Antonio BenabarreBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Susanne BengesserDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Joanna M BiernackaDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9350-4440
Armin BirnerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Clara Brichant-PetitjeanINSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Pablo CervantesThe Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.
Hsi-Chung ChenDepartment of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0003-3191-0093
Caterina ChillottiUnit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
Sven CichonInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Cristiana CruceanuDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-7799-5531
Piotr M CzerskiPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.ORCID http://orcid.org/0000-0003-0745-5916
Nina DalknerDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Alexandre DayerDepartment of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.
Maria Del ZompoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
J Raymond DePauloDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Bruno ÉtainINSERM UMR-S 1144, Université Paris Diderot, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.ORCID http://orcid.org/0000-0002-5377-1488
Stephane JamainInserm U955, Translational Psychiatry laboratory, Fondation FondaMental, Créteil, France.ORCID http://orcid.org/0000-0002-4321-4100
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University Munich, Munich, Germany.
Andreas J ForstnerInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.ORCID http://orcid.org/0000-0002-1876-6368
Louise FrisenDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Mark A FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Janice M FullertonNeuroscience Research Australia, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4014-4490
Sébastien GardService de psychiatrie, Hôpital Charles Perrens, Bordeaux, France.
Julie S GarnhamDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0002-7987-4995
Fernando S GoesDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Maria Grigoroiu-SerbanescuBiometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.ORCID http://orcid.org/0000-0002-1304-6687
Paul GrofMood Disorders Center of Ottawa, Ottawa, ON, Canada.
Ryota HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.ORCID http://orcid.org/0000-0002-5941-4238
Joanna HauserPsychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.
Stefan HermsInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.ORCID http://orcid.org/0000-0002-2786-8200
Per HoffmannInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Andrea HofmannInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Esther JiménezBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.ORCID http://orcid.org/0000-0001-6929-6207
Jean-Pierre KahnService de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
Layla KassemIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Po-Hsiu KuoDepartment of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Saitama, Japan.ORCID http://orcid.org/0000-0001-7856-3952
John R KelsoeDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-3013-2333
Sarah Kittel-SchneiderDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Sebastian KliwickiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Barbara KönigDepartment of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.
Ichiro KusumiDepartment of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.ORCID http://orcid.org/0000-0002-8747-5070
Gonzalo LajeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Mikael LandénInstitute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-4496-6451
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4987-2718
Marion LeboyerInserm U955, Translational Psychiatry laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France.
Susan G LeckbandOffice of Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.
Alfonso TortorellaDepartment of Psychiatry, University of Perugia, Perugia, Italy.
Mirko ManchiaSection of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Lina MartinssonDepartment of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
Michael J McCarthyDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-6219-4945
Susan L McElroyDepartment of Psychiatry, Lindner Center of Hope / University of Cincinnati, Mason, OH, USA.
Francesc ColomMental Health Research Group, IMIM-Hospital del Mar, Barcelona, Catalonia, Spain.
Marina MitjansUnitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain.
Francis M MondimoreDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Palmiero MonteleoneNeurosciences Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Caroline M NievergeltDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-5766-8923
Markus M NöthenInstitute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
Tomas NovákNational Institute of Mental Health, Klecany, Czech Republic.ORCID http://orcid.org/0000-0001-9156-9654
Claire O'DonovanDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Norio OzakiDepartment of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7360-4898
Urban ÖsbyDepartment of Neurobiology, Care Sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Andrea PfennigDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.
James B PotashDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-0992-634X
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Eva ReininghausDepartment of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Janusz K RybakowskiDepartment of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Martin SchallingDepartment of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Peter R SchofieldNeuroscience Research Australia, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Barbara W SchweizerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Giovanni SeverinoDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Paul D ShillingDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Katzutaka ShimodaDepartment of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Christian SimhandlBipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.
Claire M SlaneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Alessio SquassinaDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0001-7415-7607
Thomas StammDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Pavla StopkovaNational Institute of Mental Health, Klecany, Czech Republic.ORCID http://orcid.org/0000-0003-2712-3652
Mario MajDepartment of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
Gustavo TureckiDouglas Mental Health University Institute, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-4075-2736
Eduard VietaBipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Julia VeehDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1571-1468
Adam WrightSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.
Peter P ZandiDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Philip B MitchellSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-7954-5235
Michael BauerDepartment of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-2666-859X
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0001-9544-3944
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.ORCID http://orcid.org/0000-0002-5236-6149
Francis J McMahonIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9469-305X
Thomas G SchulzeIntramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.
Bernhard T BauneDepartment of Psychiatry and Psychotherapy, University of Münster, Münster, Germany. bernhard.baune@ukmuenster.de.
University of Bonn · DEThe University of Queensland · AUJohns Hopkins University · USAarhus University · DKAmsterdam Public Health · NLHeidelberg University · DEKing's College London · GBKarolinska Institutet · SEQIMR Berghofer Medical Research Institute · AUUnited States Department of Health and Human Services · USDalhousie University · CAGGZ inGeest · NLUniversity of California San Diego · USUniversity of Edinburgh · GBCardiff University · GBInserm · FRKaiser Permanente · USKarolinska University Hospital · SEUniversitätsmedizin Greifswald · DEUniversity of Cagliari · IT
Funding
Identification of Genes Involved in Major Mood DisordersZIAMH002843 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$24.5MGenetic Determinants of Antidepressant Response in the STAR*D CohortZIAMH002844 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$11.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059534 · NIMH · WASHINGTON UNIVERSITY · PI RICE, JOHN P. · 1998 to 2007
$3.1MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059533 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MACKINNON, DEAN FREDERICK · 1998 to 2007
$2.4MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH060068 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI BYERLEY, WILLIAM · 1998 to 2007
$2.1MMapping genes that contribute to bipolar disorderZ01MH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2003 to 2008
$2.0MCollaborative Genomic Study of Bipolar DisorderR01MH059548 · NIMH · UNIVERSITY OF IOWA · PI CORYELL, WILLIAM HENRY · 1998 to 2007
$1.9MCOLLABORATIVE STUDY OF BIPOLAR DISORDERR01MH059535 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S · 1998 to 2007
$1.9MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059567 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KELSOE, JOHN R. · 1998 to 2007
$1.8MCOLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDERR01MH059556 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI SCHEFTNER, WILLIAM A · 1998 to 2007
$1.6MHuman Genetics of Addiction: A Study of Common and Specific FactorsK02DA021237 · NIDA · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2007 to 2011
$567kCircadian Rhythms in Neuronal Models of Bipolar DisorderI01BX003431 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI MCCARTHY, MICHAEL JOSEPH · 2017 to 2025
–BLRD VA I01 BX003431Intramural NIH HHS Z01 MH002810Medical Research Council G0200243Medical Research Council G0801418Medical Research Council MR/L010305/1Medical Research Council MR/L023784/2Medical Research Council MR/T04604X/1NIDA NIH HHS K02 DA021237NIMH NIH HHS R01 MH059533NIMH NIH HHS R01 MH059534NIMH NIH HHS R01 MH059535NIMH NIH HHS R01 MH059548NIMH NIH HHS R01 MH059556NIMH NIH HHS R01 MH059567NIMH NIH HHS R01 MH060068
Abstract
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLi
Indexed as
Bipolar DisorderMajor Depressive DisorderDepressionGenome-Wide Association StudyHumansLithiumLithium
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