ArticleThe ISME journal2020
Burkholderia insecticola triggers midgut closure in the bean bug Riptortus pedestris to prevent secondary bacterial infections of midgut crypts.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 76 citations in OpenAlex.
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- Late is not great: fitness implications of delayed symbiont acquisition.Frontiers in microbiology · 2026Article
- Symbiont Gene Expression Predicts Insect Host's Response to High Temperatures.Molecular ecology · 2025Article
- Cultivation of Bdelloid RotiferBiology · 2025Article
- Origin and function of beneficial bacterial symbioses in insects.Nature reviews. Microbiology · 2025Review
- Dynamic reciprocal morphological changes in insect hosts and bacterial symbionts.The Journal of experimental biology · 2025Article
- Peculiar structural features of midgut symbiotic organ in the early development of the stinkbug Plautia stali Scott, 1874 (Hemiptera: Pentatomidae).Die Naturwissenschaften · 2025Article
- Temperature influences outcomes of an environmentally acquired symbiosis.The ISME journal · 2025Article
- Strict gut symbiont specificity in Coreoidea insects governed by interspecies competition within Caballeronia strains.The ISME journal · 2025Article
- The intestinal microbial community and function ofFrontiers in microbiology · 2025Article
- A strong priority effect in the assembly of a specialized insect-microbe symbiosis.Applied and environmental microbiology · 2024Article
- Large-Scale Sampling Reveals the Strain-Level Diversity ofMicroorganisms · 2024Article
- The plant-sucking insect selects assembly of the gut microbiota from environment to enhance host reproduction.NPJ biofilms and microbiomes · 2024Article
- Insect-microbe interactions and their influence on organisms and ecosystems.Ecology and evolution · 2024Review
- Hundreds of antimicrobial peptides create a selective barrier for insect gut symbionts.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The importance of host physical niches for the stability of gut microbiome composition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Interaction ofMicroorganisms · 2024Review
- Ingested soil bacteria breach gut epithelia and prime systemic immunity in an insect.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to abiotic triggers, biotic factors such as microbial symbionts can alter development of multicellular organisms. Symbiont-mediated morphogenesis is well-investigated in plants and marine invertebrates but rarely in insects despite the enormous diversity of insect-microbe symbioses. The bean bug Riptortus pedestris is associated with Burkholderia insecticola which are acquired from the environmental soil and housed in midgut crypts. To sort symbionts from soil microbiota, the bean bug develops a specific organ called the "constricted region" (CR), a narrow and symbiont-selective channel, located in the midgut immediately upstream of the crypt-bearing region. In this study, inoculation of fluorescent protein-labeled symbionts followed by spatiotemporal microscopic observations revealed that after the initial passage of symbionts through the CR, it closes within 12-18 h, blocking any potential subsequent infection events. The "midgut closure" developmental response was irreversible, even after symbiont removal from the crypts by antibiotics. It never occurred in aposymbiotic insects, nor in insects infected with nonsymbiotic bacteria or B. insecticola mutants unable to cross the CR. However, species of the genus Burkholderia and its outgroup Pandoraea that can pass the CR and partially colonize the midgut crypts induce the morphological alteration, suggesting that the molecular trigger signaling the midgut closure is conserved in this bacterial lineage. We propose that this drastic and quick alteration of the midgut morphology in response to symbiont infection is a mechanism for stabilizing the insect-microbe gut symbiosis and contributes to host-symbiont specificity in a symbiosis without vertical transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.