Evidence map›Paper›PMID 32203100›Full record

ReviewExperimental & molecular medicine2020

Mechanisms of ultrafine particle-induced respiratory health effects.

George D Leikauf, Sang-Heon Kim, An-Soo Jang

Abstract readReview
In one paragraph

Review in Experimental & molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed.

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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George D LeikaufDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, USA.
Sang-Heon KimDepartment of Internal Medicine, Hanyang University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-8398-4444
An-Soo JangDepartment of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea. jas877@schmc.ac.kr.ORCID http://orcid.org/0000-0001-5343-023X

Funding

Improving our mechanistic understanding of Electronic-cigarette, or vaping, product use-associated lung injuryU01ES015675 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEIKAUF, GEORGE DOUGLAS · 2006 to 2020
$8.9M
GENETIC DETERMINATION OF ACUTE LUNG INJURYR01HL065612 · NHLBI · UNIVERSITY OF CINCINNATI · PI LEIKAUF, GEORGE DOUGLAS · 2000 to 2004
$1.5M
Growth Factor Protection in Acute Lung InjuryR01HL077763 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEIKAUF, GEORGE DOUGLAS · 2006 to 2009
$1.4M
NHLBI NIH HHS R01 HL065612NHLBI NIH HHS R01 HL077763NIEHS NIH HHS U01 ES015675
6 · The paper itself

Abstract

Particulate matter (PM) is the principal component of air pollution. PM includes a range of particle sizes, such as coarse, fine, and ultrafine particles. Particles that are <100 nm in diameter are defined as ultrafine particles (UFPs). UFPs are found to a large extent in urban air as both singlet and aggregated particles. UFPs are classified into two major categories based on their source. Typically, UFPs are incidentally generated in the environment, often as byproducts of fossil fuel combustion, condensation of semivolatile substances or industrial emissions, whereas nanoparticles are manufactured through controlled engineering processes. The primary exposure mechanism of PM is inhalation. Inhalation of PM exacerbates respiratory symptoms in patients with chronic airway diseases, but the mechanisms underlying this response remain unclear. This review offers insights into the mechanisms by which particles, including UFPs, influence airway inflammation and discusses several mechanisms that may explain the relationship between particulate air pollutants and human health, particularly respiratory health. Understanding the mechanisms of PM-mediated lung injury will enhance efforts to protect at-risk individuals from the harmful health effects of air pollutants.

Indexed as

Air PollutantsAir PollutionAnimalsEnvironmental ExposureHumansInflammationParticle SizeParticulate MatterPneumoniaAir PollutantsParticulate Matter

Identifiers

PMID32203100
PMCPMC7156674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.