ArticleProstate cancer and prostatic diseases2020
Preoperative frailty predicts adverse short-term postoperative outcomes in patients treated with radical prostatectomy.
Article in Prostate cancer and prostatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Impact of frailty on overall survival and complications in patients with prostate cancer: a systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- Preoperative frailty and postoperative complications after non-cardiac surgery: a systematic review.The Journal of international medical research · 2024Pooled it
- The Association of Frailty with Outcomes after Cancer Surgery: A Systematic Review and Metaanalysis.Annals of surgical oncology · 2022Pooled it
- Short-term home-based multimodal prehabilitation for perioperative functional recovery in prefrail and frail older men undergoing radical prostatectomy: a randomized controlled trial.BMC geriatrics · 2026Trial
- Frailty and Social Isolation of Elderly Prostate Cancer Patients: A Chain Mediating and Network Analysis of Illness Perception and Acceptance.Nursing open · 2026Article
- Frailty and malnutrition scores in predicting postoperative complications in minimally invasive prostatectomy for malignancy of the prostate.Journal of robotic surgery · 2025Article
- The relationship between frailty and depression in Chinese elderly prostate cancer patients following radical surgery: the mediating effect of sleep disturbances.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Frailty as Predictor for Early Functional Outcomes After Radical Prostatectomy.Journal of frailty, sarcopenia and falls · 2025Article
- Development, Reliability, and Validity of Comprehensive Frailty Assessment Tool for Older Adults with Cancer (FOAC) in China.Clinical interventions in aging · 2025Article
- Ability of clock drawing errors on Mini-Cog test to predict development of delirium after major urological cancer surgery.Current urology · 2025Article
- Comprehensive geriatric assessment predicts radiation-induced acute toxicity in prostate cancer patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- The 5-Factor Modified Frailty Index is effective in treatment decision and the determination of perioperative complications in patients with localized prostate cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Article
- Frailty as a risk marker of adverse lower urinary symptom outcomes in patients with benign prostatic hyperplasia undergoing transurethral resection of prostate.Frontiers in medicine · 2023Article
- Differences in rates of pelvic lymph node dissection in National Comprehensive Cancer Network favorable, unfavorable intermediate- and high-risk prostate cancer across United States SEER registries.Current urology · 2022Article
- Does the 5-item Frailty Index predict surgical complications of endoscopic surgical management for benign prostatic obstruction? An analysis of the ACS-NSQIP.World journal of urology · 2022Article
- Surgical Tolerability and Frailty in Elderly Patients Undergoing Robot-Assisted Radical Prostatectomy: A Narrative Review.Cancers · 2022Review
- Racial differences in the distribution of bladder cancer metastases: a population-based analysis.Central European journal of urology · 2020Article
- Frailty scoring systems in urological surgery: Current status and future perspectives.Urology annalsReview
- Preoperative MELD score predicts mortality and adverse outcomes following radical cystectomy: analysis of American College of Surgeons National Surgical Quality Improvement Program.Therapeutic advances in urologyArticle
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the effect of frailty on short-term postoperative outcomes in patients with prostate cancer treated with radical prostatectomy (RP).
methodsWithin the National Inpatient Sample database, we identified 91,618 RP patients treated between 2008 and 2015. The Johns Hopkins Adjusted Clinical Groups frailty-defining indicator was applied, and we examined the rates of frailty over time, as well as its effect on overall complications, major complications, nonhome-based discharge, length of stay (LOS), and total hospital charges (THCs). Time trends and multivariable logistic, Poisson and linear regression models were applied.
resultsOverall, 12,185 (13.3%) patients were frail. Rates of frail patients increased over time (from 10.3 to 18.2%; p < 0.001). Frail patients had higher rates of overall complications (16.6 vs. 8.6%), major complications (4.9 vs. 2.6%), nonhome-based discharge (5.9 vs. 5%), longer LOS (2 vs. 1), and higher THCs ($37,186 vs. $35,241) (all p < 0.001). Moreover, frailty was an independent predictor of overall complications (OR: 1.95), major complications (OR: 1.76), nonhome-based discharge (OR: 1.20), longer LOS (RR: 1.19), and higher THCs (RR: $3160) (all p < 0.001). Of frail patients, 10,418 (85.5%) neither exhibited body mass index ≥ 30 nor Charlson comorbidity index ≥ 2.
conclusionsOn average, every seventh RP patient is frail and that proportion is on the rise. Frail individuals are at higher risk of adverse short-term postoperative outcomes, that cannot be predicted by other risk factors, such as obesity or comorbidities.
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