Evidence map›Paper›PMID 32202931›Full record

ArticleCirculation. Arrhythmia and electrophysiology2020

Balance Between Rapid Delayed Rectifier K

Bence Hegyi, Ye Chen-Izu, Leighton T Izu, Sridharan Rajamani, Luiz Belardinelli, Donald M Bers, Tamás Bányász

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  8. Article
  9. Suppression of amiodarone-induced torsade de pointes by landiolol in a patient with atrial fibrillation-mediated cardiomyopathy.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021
    Article
  10. Cardiomyocyte NaBasic research in cardiology · 2021
    Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Bence HegyiDepartment of Pharmacology (B.H., Y.C.-I., L.T.I., D.M.B., T.B.), University of California, Davis.
Ye Chen-IzuDepartment of Pharmacology (B.H., Y.C.-I., L.T.I., D.M.B., T.B.), University of California, Davis.
Leighton T IzuDepartment of Pharmacology (B.H., Y.C.-I., L.T.I., D.M.B., T.B.), University of California, Davis.
Sridharan RajamaniAmgen, Inc, South San Francisco (S.R.).
Luiz BelardinelliInCarda Therapeutics, Inc, Newark, CA (L.B.).
Donald M BersDepartment of Pharmacology (B.H., Y.C.-I., L.T.I., D.M.B., T.B.), University of California, Davis.
Tamás BányászDepartment of Pharmacology (B.H., Y.C.-I., L.T.I., D.M.B., T.B.), University of California, Davis.
University B.D.T College of Engineering · INAcorda Therapeutics (United States) · USAmgen (United States) · USUniversity of Debrecen · HU

Funding

Project 3 (Mercola)P01HL141084 · NHLBI · STANFORD UNIVERSITY · PI Joseph C. Wu · 2019 to 2026
$21.1M
CaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
The Functional Connectome of the Mechanically Loaded CardiomyocyteR01HL149431 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE, IZU, LEIGHTON T. · 2020 to 2023
$2.7M
MECHANICAL LOAD EFFECT ON CARDIAC EXCITATION-CONTRACTION COUPLINGR01HL141460 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2019 to 2022
$2.6M
Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8M
Decipher Mechano-Chemo-Transduction Pathway and Function in CardiomyocytesR01HL159993 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2021 to 2022
$1.5M
Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System inR01HL090880 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZU, LEIGHTON T. · 2009 to 2012
$1.5M
NHLBI NIH HHS P01 HL141084NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL090880NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL141460NHLBI NIH HHS R01 HL142282NHLBI NIH HHS R01 HL149431NHLBI NIH HHS R01 HL159993
6 · The paper itself

Abstract

backgroundRapid delayed rectifier K

methodsPhysiological self AP-clamp was used to measure I

resultsWe found comparable amount of net charge carried by I

conclusionsOur data demonstrate that I

Indexed as

Action PotentialsHeart RateAnimalsAnti-Arrhythmia AgentsArrhythmias, CardiacDelayed Rectifier Potassium ChannelsDisease Models, AnimalHeart FailureKineticsMaleMyocytes, CardiacPotassiumRabbitsSodiumSodium ChannelsSwineAnti-Arrhythmia AgentsDelayed Rectifier Potassium ChannelsPotassiumSodiumSodium Channelsaction potentialBrugada syndromeheartlong QT syndrometetrodotoxin

Identifiers

PMID32202931
PMCPMC7331791
OpenAlexW3012719937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.