ArticleJBRA assisted reproduction2020
Blastocysts Derived From 0PN Oocytes: Genetic And Clinical Results.
Article in JBRA assisted reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- PGT-A in Advanced Maternal Age: The probability of pregnancy is increased?JBRA assisted reproduction · 2026Article
- Clinical outcomes of 1PN- and 3PN-derived blastocysts in the absence of transferable 2PN embryos: A retrospective analysis.PloS one · 2026Article
- Thoraco-Omphalopagus Conjoined Twins Following IVF With Day 5 Embryo Transfer: A Rare Case Report and Multidisciplinary Management Approach.Clinical case reports · 2025Article
- The Istanbul consensus update: a revised ESHRE/ALPHA consensus on oocyte and embryo static and dynamic morphological assessment†,‡.Human reproduction (Oxford, England) · 2025Article
- Could blastocysts derived from abnormal fertilized zygotes be used? A systematic review and meta-analysis.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Developmental potential of zygotes without pronucleus (0PN) and pregnancy outcomes after single euploid blastocyst transfers.Journal of assisted reproduction and genetics · 2025Article
- The Identification of Molecular Ploidy Status of Abnormal Pronuclear Zygotes Reveals a Significant Number of Euploid Blastocysts Available for Conception.Biomedicines · 2024Article
- Use of time-lapse technology on fertilization verification, embryo evaluation, and utilization: A national survey in Japan.AJOG global reports · 2024Article
- Developmental competence and neonatal outcomes of nonpronuclear zygotes following single vitrified-warmed blastocyst transfers using propensity score matching analysis.Archives of gynecology and obstetrics · 2024Article
- Clinical outcomes of frozen-thawed blastocysts from zygotes with no or one pronucleus for in vitro fertilization and intracytoplasmic sperm injection cycles.Archives of gynecology and obstetrics · 2023Article
- Does the cell number of 0PN embryos on day 3 affect pregnancy and neonatal outcomes following single blastocyst transfer?BMC pregnancy and childbirth · 2022Article
- Time-lapse monitoring of fertilized human oocytes focused on the incidence of 0PN embryos in conventional in vitro fertilization cycles.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyze the genetic and clinical outcomes of blastocysts derived from 0PN oocytes after IVF/ICSI.
methodsThis retrospective observational study included patients aged 40 years or younger submitted to IVF/ICSI with their own oocytes and with blastocysts derived from 0PN oocytes between January 2015 and April 2018. The clinical outcomes of 0PN blastocyst transfers were analyzed. Genetic tests were performed on biopsied 0PN blastocysts with Next Generation Sequencing.
resultsA total of 27 0PN blastocysts were transferred, yielding an implantation rate of 48.0% and an ongoing pregnancy rate of 50.0%. The transfers resulted in 13 live births (59.0% live birth rate). Genetic test results revealed that four of the 17 0PN blastocysts biopsied were 46XX; three were 46XY; and 10 were aneuploid embryos, awarding a diploid rate to 76.4% (13/17).
conclusionAlmost half of the 0PN blastocysts implanted (48.0%) and 13 healthy babies were born. More than three quarters (76.4%) of the 0PN blastocysts were diploid, thus ruling out the possibility of parthenogenetic activation. Our study indicated that the transfer of 0PN blastocysts is a safe, worthy option when the number of normal 2PN embryos is insufficient.
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