ArticleCerebral cortex (New York, N.Y. : 1991)2020
Reward Timing and Its Expression by Inhibitory Interneurons in the Mouse Primary Visual Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- An auditory cortical-striatal circuit supports sound-triggered timing to predict future events.PLoS biology · 2025Article
- Temporal pavlovian conditioning of a model spiking neural network for discrimination sequences of short time intervals.Journal of computational neuroscience · 2025Article
- Learning to express reward prediction error-like dopaminergic activity requires plastic representations of time.Nature communications · 2024Article
- M2 receptors are required for spatiotemporal sequence learning in mouse primary visual cortex.Journal of neurophysiology · 2024Article
- A Cortico-Striatal Circuit for Sound-Triggered Prediction of Reward Timing.bioRxiv : the preprint server for biology · 2023Article
- Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Optogenetic manipulation of inhibitory interneurons can be used to validate a model of spatiotemporal sequence learning.Frontiers in computational neuroscience · 2023Article
- Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment.eLife · 2022Article
- Portrait of visual cortical circuits for generating neural oscillation dynamics.Cognitive neurodynamics · 2021Review
- Visual Cues Predictive of Behaviorally Neutral Outcomes Evoke Persistent but Not Interval Timing Activity in V1, Whereas Aversive Conditioning Suppresses This Activity.Frontiers in systems neuroscience · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
The primary sensory cortex has historically been studied as a low-level feature detector, but has more recently been implicated in many higher-level cognitive functions. For instance, after an animal learns that a light predicts water at a fixed delay, neurons in the primary visual cortex (V1) can produce "reward timing activity" (i.e., spike modulation of various forms that relate the interval between the visual stimulus and expected reward). Local manipulations to V1 implicate it as a site of learning reward timing activity (as opposed to simply reporting timing information from another region via feedback input). However, the manner by which V1 then produces these representations is unknown. Here, we combine behavior, in vivo electrophysiology, and optogenetics to investigate the characteristics of and circuit mechanisms underlying V1 reward timing in the head-fixed mouse. We find that reward timing activity is present in mouse V1, that inhibitory interneurons participate in reward timing, and that these representations are consistent with a theorized network architecture. Together, these results deepen our understanding of V1 reward timing and the manner by which it is produced.
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