Evidence map›Paper›PMID 32202500›Full record

ArticleeLife2020

Identification of a molecular basis for the juvenile sleep state.

Leela Chakravarti Dilley, Milan Szuperak, Naihua N Gong, Charlette E Williams, Ricardo Linares Saldana, David S Garbe, Mubarak Hussain Syed, Rajan Jain, Matthew S Kayser

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Early life sleep is associated with longevity inbioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Evo-devo applied to sleep research: an approach whose time has come.Sleep advances : a journal of the Sleep Research Society · 2024
    Review
  7. Neurobiology of sleep and circadian rhythms · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. TheiScience · 2022
    Article
  13. eLife · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Leela Chakravarti DilleyDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-8115-6821
Milan SzuperakDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Naihua N GongDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Charlette E WilliamsDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Ricardo Linares SaldanaDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-2657-825X
David S GarbeDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Mubarak Hussain SyedDepartment of Biology, University of New Mexico, Albuquerque, United States.ORCID 0000-0003-2424-175X
Rajan JainDepartment of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Matthew S KayserDepartment of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-2359-4967
University of Pennsylvania · USUniversity of New Mexico · US

Funding

Training in Sleep & Sleep DisordersT32HL007953 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI David Menassah Raizen, AMY M SAWYER · 2000 to 2026
$10.6M
Building brains in our sleep: A Drosophila larval platform for examining sleep and neurogenesisDP2NS111996 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAYSER, MATTHEW S · 2018 to 2018
$2.4M
The Role of BRD4 in Cardiac SpecificationR01HL139783 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN · 2019 to 2022
$1.6M
A critical period of sleep required for normal brain developmentK08NS090461 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAYSER, MATTHEW S · 2014 to 2018
$952k
Investigating the genetic control of early life sleep using DrosophilaF31NS105447 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DILLEY, LEELA CHAKRAVARTI · 2017 to 2017
$49k
NHLBI NIH HHS R01 HL139783NHLBI NIH HHS T32 HL007953NIH HHS F31 NS105447NIH HHS T32 HL007953NINDS NIH HHS DP2 NS111996NINDS NIH HHS F31 NS105447NINDS NIH HHS K08 NS090461
6 · The paper itself

Abstract

Across species, sleep in young animals is critical for normal brain maturation. The molecular determinants of early life sleep remain unknown. Through an RNAi-based screen, we identified a gene,

Indexed as

AnimalsCircadian RhythmDopaminergic NeuronsDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesMicrofilament ProteinsMuscle ProteinsPOU Domain FactorsRNA InterferenceSexual Behavior, AnimalSignal TransductionSleepDrosophila ProteinsMicrofilament ProteinsMsp300 protein, DrosophilaMuscle ProteinsPdm3 protein, DrosophilaPOU Domain Factorscentral complexdevelopmentD. melanogasterdopaminegeneticsgenomicsneuroscienceontogenysleepsynapse

Identifiers

PMID32202500
PMCPMC7185995
OpenAlexW3005820833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.