Evidence map›Paper›PMID 32202291›Full record

ArticleSoft matter2020

Photo-tunable hydrogel mechanical heterogeneity informed by predictive transport kinetics model.

Callie I Higgins, Jason P Killgore, Frank W DelRio, Stephanie J Bryant, Robert R McLeod

Abstract read
In one paragraph

Article in Soft matter, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Tunable Blood Shunt for Neonates With Complex Congenital Heart Defects.Frontiers in bioengineering and biotechnology · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Callie I HigginsApplied Chemicals and Materials Division, Material Measurement Laboratory, National Institute of Standards and Technology, 325 Broadway, Boulder, CO 80305, USA. callie.higgins@nist.gov.
Jason P Killgore
Frank W DelRio
Stephanie J Bryant
Robert R McLeod

Funding

Mechanically Stiff Hydrogels for Osteochondral Tissue EngineeringR01AR069060 · NIAMS · UNIVERSITY OF COLORADO · PI Stephanie J Bryant · 2016 to 2026
$4.1M
NIAMS NIH HHS R01 AR069060
6 · The paper itself

Abstract

Understanding the three-dimensional (3D) mechanical and chemical properties of distinctly different, adjacent biological tissues is crucial to mimicking their complex properties with materials. 3D printing is a technique often employed to spatially control the distribution of the biomaterials, such as hydrogels, of interest, but it is difficult to print both mechanically robust (high modulus and toughness) and biocompatible (low modulus) hydrogels in a single structure. Moreover, due to the fast diffusion of mobile species during printing and nonequilibrium swelling conditions of low-solids-content hydrogels, it is challenging to form the high-fidelity structures required to mimic tissues. Here a predictive transport and swelling model is presented to model these effects and then is used to compensate for these effects during printing. This model is validated experimentally by photopatterning spatially distinct hydrogel elastic moduli using a single photo-tunable poly(ethylene glycol) (PEG) pre-polymer solution by sequentially patterning and in-diffusing fresh pre-polymer for further polymerization.

Identifiers

PMID32202291
PMCPMC7489306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.