ReviewAngewandte Chemie (International ed. in English)2021
Iridium-Catalysed C-H Borylation of Heteroarenes: Balancing Steric and Electronic Regiocontrol.
Review in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 165 citations in OpenAlex.
- Flash Communication: Arene ηOrganometallics · 2026Article
- Photoinduced Palladium-Catalyzed Site-Selective Meta-Alkylation of Pyridines.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Origins of the selectivity of late transition metals of Group 9 and Group 10 for oxidative addition of C-HChemical science · 2026Article
- Regioselective Iridium-Catalyzed C(7)-H Borylation of FreeACS omega · 2026Article
- Boron in Diet and Medicine: Mechanisms of Delivery and Detection.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Electronic Activation Enables the Borylation of Alkyl C-H Bonds in Saturated Nitrogen Heterocycles.Journal of the American Chemical Society · 2025Article
- Catalytic aromatic C-H borylation via strained Si and Ge metallacycles.Nature communications · 2025Article
- Solventless Catalytic C-H and C-X Functionalization without Ball Milling.The Journal of organic chemistry · 2025Article
- An Oxygen Walk Approach for C3 Selective Hydroxylation of Pyridines.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025Article
- The Importance of Atomic Charges for Predicting Site-Selective Ir-, Ru-, and Rh-Catalyzed C-H Borylations.The Journal of organic chemistry · 2025Article
- Computational tools for the prediction of site- and regioselectivity of organic reactions.Chemical science · 2025Review
- High-Throughput Enabled Iridium-Catalyzed C-H Borylation Platform for Late-Stage Functionalization.ACS catalysis · 2025Article
- An Air-Stable, Single-Component Iridium Precatalyst for the Borylation of C-H Bonds on Large to Miniaturized Scales.Journal of the American Chemical Society · 2024Article
- Mechanistic Studies and Identification of Catalyst Deactivation Pathways for Pyridine(diimine) Iron Catalyzed C(spACS catalysis · 2024Article
- C3 Selective Hydroxylation of Pyridines via Photochemical Valence Isomerization of PyridineJournal of the American Chemical Society · 2024Article
- C3 Selective chalcogenation and fluorination of pyridine using classic Zincke imine intermediates.Nature communications · 2024Article
- Selective Synthesis of Boron-Functionalized Indenes and Benzofulvenes by BClOrganic letters · 2024Article
- Repurposing a supramolecular iridium catalystChemical science · 2024Article
- Derivatization of 2,1,3-Benzothiadiazole via Regioselective C-H Functionalization and Aryne Reactivity.The Journal of organic chemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The iridium-catalysed borylation of aromatic C-H bonds has become the preferred method for the synthesis of aromatic organoboron compounds. The reaction is highly efficient, tolerant of a broad range of substituents and can be applied to both carbocyclic and heterocyclic substrates. The regioselectivity of C-H activation is dominated by steric considerations and there have been considerable efforts to develop more selective processes for less constrained substrates. However, most of these have focused on benzenoid-type substrates and in contrast, heteroarenes remain much desired but more challenging substrates with the position and/or nature of the heteroatom(s) significantly affecting reactivity and regioselectivity. This review will survey the borylation of heteroarenes, focusing on the influence of steric and electronic effects on regiochemical outcome and, by linking to current mechanistic understandings, will provide insights to what is currently possible and where further developments are required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.