ArticleThe American journal on addictions2020
Incidence of Postoperative Opioid Overdose and New Diagnosis of Opioid Use Disorder Among US Veterans.
Article in The American journal on addictions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04770480 (Exploring Non-pharmacological Approaches to Pain Management After Lumbar Surgery), which is not on this map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exploring Non-pharmacological Approaches to Pain Management After Lumbar Surgery: A Randomized Controlled Trial
Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- The incidence of persistent postoperative opioid use among U.S. veterans: A national study to identify risk factors.Journal of clinical anesthesia · 2021Trial
- Buprenorphine versus full agonist opioids for acute postoperative pain management: an infographic.Regional anesthesia and pain medicine · 2026Article
- PostRegional anesthesia and pain medicine · 2025Article
- Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis.International journal of impotence research · 2024Article
- Perioperative opioid prescribing and iatrogenic opioid use disorder and overdose: a state-of-the-art narrative review.Regional anesthesia and pain medicine · 2024Review
- The acceptability and utility of opioid and other high-risk substance use screening as implemented within the perioperative workflow.Pain medicine (Malden, Mass.) · 2023Article
- Lessons from the implementation of a trauma center-based program to support primary care providers in managing opioids and pain after trauma hospitalization.Trauma surgery & acute care open · 2023Article
- Long-acting liposomal bupivacaine and postoperative opioid use after Peyronie's disease surgery: a pilot study.Translational andrology and urology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesPerioperative exposure to opioids is associated with adverse outcomes. We aim to determine the associations between surgery and subsequent opioid overdose, an acute event, and a new diagnosis of opioid use disorder (OUD), a chronic relapsing disease, in parallel.
methodsThis retrospective cohort study of US veterans used surgery as exposure and the two outcomes were (1) occurrence of overdose and (2) new diagnosis of OUD in the first postoperative year. Surgical group was matched to the reference controls based on the propensity score of having surgery, and matched logistic regression was used to calculate the odds ratio (OR).
resultsA total of 261 208 surgical patients were matched to 479 531 controls. Overdose occurred in 1893 (0.7%) of the surgical patients and in 518 (0.1%) of the matched controls in the first postoperative year (OR, 6.71; 95% confidence interval [CI], 5.80-7.75; P < .001). Among patients with no history of OUD, surgery was also associated with a new diagnosis of OUD in the first postoperative year (OR, 1.13; 95% CI, 1.02-1.24; P = .015). DISCUSSION AND
conclusionsThe postoperative period is strongly associated with opioid overdose, but only weakly associated with new diagnosis of OUD. This is likely due to the difficulty of diagnosing OUD in the postoperative period. SCIENTIFIC SIGNIFICANCE: This is the first study that has examined opioid overdose and new-onset OUD in the postoperative period in parallel. Our analysis suggests different risk factors for each, as well as different strengths of association with surgery. More sensitive diagnostic criteria for postoperative OUD are needed to promptly diagnose and treat this condition. (Am J Addict 2020;00:00-00).
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