Evidence map›Paper›PMID 32201997›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2020

Tunable Fano-Resonant Metasurfaces on a Disposable Plastic-Template for Multimodal and Multiplex Biosensing.

Rajib Ahmed, Mehmet Ozgun Ozen, Merve Goksin Karaaslan, Cecilia A Prator, Cassandra Thanh, Shreya Kumar, Leonel Torres, Nikita Iyer, Sadie Munter, Sarka Southern and 3 more

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Enhanced Spectral Tunability by Sub-10 nm Nanogaps in Graphene-Metal Hybrid Metasurfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  7. Review
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  16. Pedestal High-Contrast Gratings for Biosensing.Nanomaterials (Basel, Switzerland) · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rajib AhmedBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.
Mehmet Ozgun OzenBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.
Merve Goksin KaraaslanBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.
Cecilia A PratorDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Cassandra ThanhDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Shreya KumarDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Leonel TorresDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Nikita IyerDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Sadie MunterDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Sarka SouthernSchool of Medicine, Gaia Medical Institute, 505 Coast Boulevard South, La Jolla, CA, 92037, USA.
Timothy J HenrichDivision of Experimental Medicine, University of California, 1001 Potrero Avenue, San Francisco, CA, 94110, USA.
Fatih InciBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.
Utkan DemirciBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.ORCID https://orcid.org/0000-0003-2784-1590

Funding

Platform technology for detection of cancer-associated viruses in HIV patientsR01DE024971 · NIDCR · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN, KAYE, KENNETH M · 2015 to 2019
$2.1M
Portable Nanostructured Photonic Crystal Device for HIV-1 Viral LoadR01AI120683 · NIAID · STANFORD UNIVERSITY · PI CUNNINGHAM, BRIAN T., DEMIRCI, UTKAN · 2016 to 2019
$1.5M
Rapid oral test for Influenza A+B diagnosticsR44DE021672 · NIDCR · GAIA MEDICAL INSTITUTE, INC. · PI DEMIRCI, UTKAN, GRIFFIN, TIMOTHY J. · 2016 to 2018
$971k
NIAID NIH HHS R01 AI120683NIDCR NIH HHS R01 DE024971NIDCR NIH HHS R44 DE021672NIH HHS R01 AI120683NIH HHS R01 DE024971NIH HHS R44 DE021672
6 · The paper itself

Abstract

Metasurfaces are engineered nanostructured interfaces that extend the photonic behavior of natural materials, and they spur many breakthroughs in multiple fields, including quantum optics, optoelectronics, and biosensing. Recent advances in metasurface nanofabrication enable precise manipulation of light-matter interactions at subwavelength scales. However, current fabrication methods are costly and time-consuming and have a small active area with low reproducibility due to limitations in lithography, where sensing nanosized rare biotargets requires a wide active surface area for efficient binding and detection. Here, a plastic-templated tunable metasurface with a large active area and periodic metal-dielectric layers to excite plasmonic Fano resonance transitions providing multimodal and multiplex sensing of small biotargets, such as proteins and viruses, is introduced. The tunable Fano resonance feature of the metasurface is enabled via chemical etching steps to manage nanoperiodicity of the plastic template decorated with plasmonic layers and surrounding dielectric medium. This metasurface integrated with microfluidics further enhances the light-matter interactions over a wide sensing area, extending data collection from 3D to 4D by tracking real-time biomolecular binding events. Overall, this work resolves cost- and complexity-related large-scale fabrication challenges and improves multilayer sensitivity of detection in biosensing applications.

Indexed as

Biosensing TechniquesModels, MolecularMolecular ConformationSurface Propertiesbiosensingmetasurfacesmicrofluidicspoint-of-care diagnosticstunable Fano resonances

Identifiers

PMID32201997
PMCPMC8713081

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.