SynthesisActa diabetologica2020
Changes in corneal biomechanics in patients with diabetes mellitus: a systematic review and meta-analysis.
Synthesis in Acta diabetologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effect of Diabetes Mellitus on Central Corneal Thickness Values: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Adaptive Temporal Mixture of Experts for Predicting Stiffness Metrics From the Ocular Response Analyzer and Identifying Keratoconus.American journal of ophthalmology · 2026Observational
- Influence of inflammatory and metabolic factors on keratoconus risk: a causal inference analysis.Eye (London, England) · 2026Article
- Corneal Structural Alterations Under Chronic Hyperglycemia: Biomechanical and Densitometric Insights in Type 2 Diabetes with and Without Retinopathy.Beyoglu eye journal · 2026Article
- Corneal Epithelial Changes in Diabetic Patients: A Review.International journal of molecular sciences · 2024Review
- Analysis of Corneal Deformation in Paediatric Patients Affected by Maturity Onset Diabetes of the Young Type 2.Diagnostics (Basel, Switzerland) · 2023Article
- Diabetic Retinopathy: Soluble and Imaging Ocular Biomarkers.Journal of clinical medicine · 2023Review
- Comparison of anterior segment parameters of the eye between type 2 diabetic with and without diabetic retinopathy and non-diabetic.International journal of ophthalmology · 2023Article
- The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts.Ophthalmology · 2022Article
- Biomechanical analysis of ocular diseases and its in vitro study methods.Biomedical engineering online · 2022Review
- Systemic diseases and the cornea.Experimental eye research · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the changes in corneal biomechanical parameters in patients with diabetes mellitus (DM) in comparison with controls.
methodsPertinent studies were identified by comprehensively search of PubMed, Embase, the Web of Science, the Cochrane Library, Scopus, the China National Knowledge Infrastructure and the Chinese biomedical disc (CBM) databases. Pooling analyses by random models using the D-L method were performed for corneal hysteresis (CH), the corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc) and Goldmann-correlated intraocular pressure (IOPg).
resultsA total of 15 studies were included in the final analysis, involving 1506 eyes in the diabetic group and 2190 eyes in the control group. The diabetic group had significantly higher CH, CRF, IOPg and IOPcc values than the control group. The pooled mean differences were 1.34 mmHg (95% confidence interval [CI] 0.60-2.08 mmHg, P < 0.001) for IOPg and 0.85 mmHg (95% CI 0.18-1.51 mmHg, P = 0.013) for IOPcc, 0.38 mmHg (95% CI 0.01-0.75, P = 0.047) for CH and 0.63 mmHg (95% CI 0.27-0.98, P = 0.001) for the CRF. Sensitivity analyses using the leave-one-out method showed a consistent significant difference between the groups (all P < 0.001).
conclusionsCorneal biomechanics changed in the patients with DM. High CH, CRF, IOPcc and IOPg values may be associated factors for diabetes mellitus. Future studies are warranted to clarify the underlying mechanisms and explore the relationship between corneal biomechanics, glaucoma and diabetes mellitus. REGISTRATION: PROSPERO registration No CRD4201705465.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.