ArticleDiabetologia2020
Early puberty and risk for type 2 diabetes in men.
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.Acta bio-medica : Atenei Parmensis · 2023Pooled it
- Diagnostic Accuracy of Female Pelvic Ultrasonography in Differentiating Precocious Puberty From Premature Thelarche: A Systematic Review and Meta-analysis.Frontiers in endocrinology · 2021Pooled it
- Comparing epigenetic puberty and epigenetic clocks as biomarkers of adult biological aging and health.medRxiv : the preprint server for health sciences · 2026Article
- Association between pubertal timing and bone and body composition in young adult men.Scientific reports · 2025Observational
- Prenatal, newborn and childhood factors and the timing of puberty in boys and girls.Pediatric research · 2024Article
- Novel signals and polygenic score for height are associated with pubertal growth traits in Southwestern American Indians.Human molecular genetics · 2024Article
- Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.Genome biology · 2024Article
- Early puberty: a review on its role as a risk factor for metabolic and mental disorders.Frontiers in pediatrics · 2024Review
- Adolescent Growth Spurt and Type 2 Diabetes Risk in Southwestern American Indians.American journal of epidemiology · 2023Article
- A retrospective cohort study on the association between poor sleep quality in junior high school students and high hemoglobin A1c level in early adults with higher body mass index values.BMC endocrine disorders · 2022Article
- Bring the life stages into the domain of basic and clinical pharmacology.Frontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aims/hypothesisThe association between pubertal timing and type 2 diabetes, independent of prepubertal BMI, is not fully understood. The aim of the present study was to evaluate the association between pubertal timing and risk of adult type 2 diabetes, independent of prepubertal BMI, in Swedish men.
methodsWe included 30,697 men who had data for BMI at age 8 and 20 years and age at Peak Height Velocity (PHV), an objective assessment of pubertal timing, available from the BMI Epidemiology Study Gothenburg (BEST Gothenburg), Sweden. Information on type 2 diabetes (n = 1851) was retrieved from the Swedish National Patient Register. HRs and 95% CIs were estimated by Cox regression analysis. We observed violations of the assumption of proportional hazards for the association between age at PHV and the risk of type 2 diabetes and therefore split the follow-up period at the median age of type 2 diabetes diagnosis (57.2 years of age) to define early (≤57.2 years) and late (>57.2 years) type 2 diabetes diagnosis.
resultsAge at PHV was inversely associated with both early (HR 1.28 per year decrease in age at PHV, 95% CI 1.21, 1.36) and late (HR 1.13, 95% CI 1.06, 1.19) type 2 diabetes. After adjustment for childhood BMI, the associations between age at PHV and both early (HR 1.24, 95% CI 1.17, 1.31) and late (HR 1.11, 95% CI 1.05, 1.17) type 2 diabetes were similar. Moreover, early age at PHV predicted insulin treatment of type 2 diabetes (OR 1.25 per year decrease in age at PHV, 95% CI 1.17, 1.33). Assuming a higher risk among those with an age at PHV below the median, the population attributable factor indicates that 15% fewer of the diagnosed individuals would have developed type 2 diabetes had they not reached puberty early. CONCLUSIONS/
interpretationThese findings indicate that early puberty may be a novel independent risk factor for type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.