Evidence map›Paper›PMID 32201779›Full record

ArticleACS omega2020

Selective Intracellular Delivery of Thiolated Cargo to Tumor and Neovasculature Cells Using Histidine-Rich Peptides as Vectors.

J Johannes Eksteen, Dominik Ausbacher, Terje Vasskog, Øystein Rekdal, John S M Svendsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

J Johannes EksteenNORCE Norwegian Research Centre AS, Siva Innovasjonssenter, Sykehusvegen 21, NO 9294 Tromsø, Norway.
Dominik AusbacherDepartment of Pharmacy, UiT Arctic University of Norway, NO 9037 Tromsø, Norway.
Terje VasskogNORCE Norwegian Research Centre AS, Siva Innovasjonssenter, Sykehusvegen 21, NO 9294 Tromsø, Norway.
Øystein RekdalLytix Biopharma AS, Siva Innovasjonssenter, Sykehusvegen 21, P.O. Box 6447, NO 9294 Tromsø, Norway.
John S M SvendsenDepartment of Chemistry, UiT Arctic University of Norway, NO 9037 Tromsø, Norway.
NORCE Research AS · NOUiT The Arctic University of Norway · NOLytix Biopharma (Norway) · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown.

Identifiers

PMID32201779
PMCPMC7081261
OpenAlexW3009265051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.