ArticleACS omega2020
Effects of Low-level Lipid Peroxidation on the Permeability of Nitroaromatic Molecules across a Membrane: A Computational Study.
Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Membrane Stress and Ferroptosis: Lipid Dynamics in Cancer.International journal of molecular sciences · 2026Review
- Advances in cold atmospheric plasma therapy for cancer.Bioactive materials · 2025Review
- Novel insights into bexarotene's role in preventing cholestasis: mechanisms and implications.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Fipronil Triggers Immunotoxicity Through Reactive Oxygen Species-Driven Mitochondrial Apoptosis in Thymocytes.Toxics · 2025Article
- Protein-free domains in native and ferroptosis-driven oxidized cell membranes: a molecular dynamics study of biophysical properties and doxorubicin uptake.Frontiers in molecular biosciences · 2024Article
- Effects of Nitro-Oxidative Stress on Biomolecules: Part 1-Non-Reactive Molecular Dynamics Simulations.Biomolecules · 2023Review
- Lipid Corona Formation on Micro- and Nanoplastic Particles Modulates Uptake and Toxicity in A549 Cells.Materials (Basel, Switzerland) · 2023Article
- Review
- Article
- Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid peroxidation (LPO) in cellular membranes can cause severe membrane damage and potential cell death. Although oxidized phospholipids have been proved to lead to great changes in the structures and properties of membranes, effects of low-level LPO on membrane permeability have not yet been fully understood. Here, we explored the molecular mechanism of low-level LPO changing the permeability of nitroaromatic molecules across a lipid bilayer by all-atom molecular dynamics simulations. The results reveal that the enhanced passive transport of nitroaromatic molecules lies in the size of defects (i.e., water "finger" and "cone"), which is further dependent on the extent of LPO and the structural feature of solutes. In detail, if the solute can form more hydrogen bonds with water, which stabilizes the water into a large-size cone, there is a greater permeability coefficient (
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.