Evidence map›Paper›PMID 32201632›Full record

ArticleAllergy & rhinology (Providence, R.I.)

Effect of Biospray Dressings on Eosinophil Infiltration in the Nasal Mucosa and Serum IgE Levels After Nasal Provocation in Experimental Allergic Rhinitis.

Shan Huang, Geping Wu, Xiaodan Gu, Hongyan Zhu, Xingkai Ma, Yifang Yuan, Yan Lv, Di Li, Ling Zhang

Open access · goldAbstract read
In one paragraph

Article in Allergy & rhinology (Providence, R.I.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. MicroRNA-29 mediates anti-inflammatory effects and alleviation of allergic responses and symptoms in mice with allergic rhinitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shan HuangYifatu Biotechnology (Wuhan) Co. Ltd., Wuhan, China.
Geping WuDepartment of Otolaryngology, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.ORCID https://orcid.org/0000-0002-7194-0716
Xiaodan GuDepartment of Otolaryngology, The Fifth People's Hospital of Zhangjiagang City, Suzhou, China.
Hongyan ZhuInstitute of Translational Medicine, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.
Xingkai MaDepartment of Otolaryngology, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.
Yifang YuanDepartment of Otolaryngology, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.
Yan LvInstitute of Translational Medicine, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.
Di LiInstitute of Translational Medicine, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.
Ling ZhangInstitute of Translational Medicine, The affiliated Zhangjiagang hospital of Soochow University, Suzhou, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the effect of biospray dressing on the extent of eosinophil infiltration in the nasal mucosa and the level of serum IgE in experimental allergic rhinitis with nasal provocation.

methodTwenty-four BALB/c mice were randomly divided into the normal control group, allergic rhinitis (AR) group, dexamethasone (DEX) treatment group, and biospray dressing (BD) group. The mice in the latter 3 groups were prepared for animal models of AR according to standard protocols. Mice in the BD group were administered a nasal spray before the nasal provocation, and those in the DEX group were administered an intraperitoneal injection of DEX. The nasal mucosa and serum were collected from each group. Nasal mucosa eosinophil infiltration was evaluated using hematoxylin and eosin staining, and enzyme-linked immunosorbent assay (ELISA) was performed to analyze the serum IgE expression.

resultsEosinophil infiltration (AR vs BD

conclusionBiospray dressings can significantly reduce allergen provocation in the nasal cavity and have a protective effect on the nasal mucosa. They can be used for the prevention and treatment of AR.

Indexed as

allergic rhinitisbiospray dressingeosinophilsserum IgE

Identifiers

PMID32201632
PMCPMC7066584
OpenAlexW3009082649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.