Evidence map›Paper›PMID 32201592›Full record

ArticleOpen heart2020

Association of smoking and right ventricular function in middle age: CARDIA study.

Henrique T Moreira, Anderson C Armstrong, Chike C Nwabuo, Henrique D Vasconcellos, Andre Schmidt, Ravi K Sharma, Bharath Ambale-Venkatesh, Mohammad R Ostovaneh, Catarina I Kiefe, Cora E Lewis and 5 more

Erratum issuedOpen access · goldAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Henrique T MoreiraDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-4543-4684
Anderson C ArmstrongDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Chike C NwabuoDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-7888-9781
Henrique D VasconcellosDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Andre SchmidtDivision of Cardiology, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
Ravi K SharmaDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Bharath Ambale-VenkateshDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Mohammad R OstovanehDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Catarina I KiefePopulation and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Cora E LewisDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Stephen SidneyDivision of Research, Kaiser Permanente Division of Research, Oakland, California, USA.
Kofo O OgunyankinDivision of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Samuel S GiddingChief Medical Officer, The FH Foundation, Passadena, California, USA.
Joao A C LimaDivision of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USFH Foundation · USKaiser Permanente · USNorthwestern University · USUniversidade de São Paulo · BRUniversity of Alabama at Birmingham · USUniversity of Massachusetts Chan Medical School · USUniversity of Minnesota · US

Funding

NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007I
6 · The paper itself

Abstract

Objective: To evaluate the association of cigarette smoking and right ventricular (RV) systolic and diastolic functions in a population-based cohort of individuals at middle age. Methods: This cross-sectional study included participants who answered the smoking questionnaire and underwent echocardiography at the Coronary Artery Risk Development in Young Adulthood year 25 examination. RV systolic function was assessed by echocardiographic-derived tricuspid annular plane systolic excursion (TAPSE) and by right ventricular peak systolic velocity (RVS'), while RV diastolic function was evaluated by early right ventricular tissue velocity (RVE'). Multivariable linear regression models assessed the relationship of smoking with RV function, adjusting for age, sex, race, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, diabetes mellitus, alcohol consumption, pulmonary function, left ventricular systolic and diastolic function and coronary artery calcium score. Results: A total of 3424 participants were included. The mean age was 50±4 years; 57% were female; and 53% were black. There were 2106 (61%) never smokers, 750 (22%) former smokers and 589 (17%) current smokers. In the multivariable analysis, current smokers had significantly lower TAPSE (β=-0.082, SE=0.031, p=0.008), RVS' (β=-0.343, SE=0.156, p=0.028) and RVE' (β=-0.715, SE=0.195, p<0.001) compared with never smokers. Former smokers had a significantly lower RVE' compared with never smokers (β=-0.414, SE=0.162, p=0.011), whereas no significant difference in RV systolic function was found between former smokers and never smokers. Conclusions: In a large multicenter community-based biracial cohort of middle-aged individuals, smoking was independently related to both worse RV systolic and diastolic functions.

Indexed as

SmokersVentricular Function, RightAge FactorsCross-Sectional StudiesEchocardiography, DopplerEx-SmokersFemaleHumansMaleMiddle AgedNon-SmokersPredictive Value of TestsRisk AssessmentRisk FactorsSmokingUnited Statescardiac functionechocardiographysmoking

Identifiers

PMID32201592
PMCPMC7061887
OpenAlexW3009715213

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.