Evidence map›Paper›PMID 32201444›Full record

ArticleIndian journal of pharmacology

Effect of chromium citrate on the mechanism of glucose transport and insulin resistance in Buffalo rat liver cells.

Weijie Zhang, Hui Chen, Yangyang Ding, Qingfang Xiang, Jie Zhao, Weiwei Feng, Liuqing Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Weijie ZhangSchool of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Hui ChenSchool of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Yangyang DingSchool of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Qingfang XiangSchool of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Jie ZhaoSchool of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Weiwei FengSchool of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Liuqing YangSchool of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur published literature indicated that chromium citrate could regulate the glycemic index in alloxaninduced diabetic mice. The present study investigated the mechanism of chromium citrate in insulin resistance (IR) buffalo rat liver (BRL) cells. MATERIALS And

methodsChromium citrate was synthesized in our laboratory. BRL cells were purchased from the Chinese Academy of Sciences Cell Bank. The glucose transport and IR affected by chromium citrate in BRL cells were examined. The Thiazolyl Blue Tetrazolium Bromide (MTT) and glucose assay experiments were measured by microplate ELISA reader. The protein kinase B (Akt), glucose transporter-4 (Glut4), and phosphor-AMP-activated protein kinase β1 levels were tested by Western blot, and the mRNA expression of glucose transport proteins (Akt2, Glut4, and AMPactivated protein kinase α2 (AMPKα2)) and insulin sensitivity proteins (insulin receptor substrate1 (IRS-1), phosphatidylinositol 3 kinase (PI3K), and peroxisome proliferator-activated receptor γ (PPARγ)) was measured by reverse transcription-polymerase chain reaction.

resultsThe results indicated that the glucose absorption level of chromium citrate groups was higher than model group significantly. It demonstrated that chromium citrate could significantly improve glucose absorption in IR BRL cells. The Akt, Glut4, and phosphor-AMPKβ1 levels in chromium citrate groups (at doses of 0.4, 0.2, and 0.1 μg Cr/mL) were markedly improved when compared with the other experiment groups, and chromium citrate could more effectively increase the Akt level than chromium trichloride. In addition, the mRNA expression of Akt2, Glut4, and AMPKα2 in chromium citrate groups was significantly improved when contrasted with model group.

conclusionThe consequences illustrated that chromium citrate can affect the IR BRL cells' ameliorating glucose transport and IR.

Indexed as

Insulin ResistanceAMP-Activated Protein KinasesAnimalsCells, CulturedCell SurvivalChromium CompoundsGlucoseGlucose Transporter Type 4Insulin Receptor Substrate ProteinsLiverPhosphatidylinositol 3-KinasesPPAR gammaProto-Oncogene Proteins c-aktRats, Inbred BUFAMP-Activated Protein KinasesChromium CompoundsGlucoseGlucose Transporter Type 4Insulin Receptor Substrate ProteinsIrs1 protein, ratPhosphatidylinositol 3-KinasesPPAR gammaProto-Oncogene Proteins c-aktSlc2a4 protein, ratDiabetes mellitusglucose absorptionreverse transcription–polymerase chain reactionWestern blot

Identifiers

PMID32201444
PMCPMC7074430
OpenAlexW3012503491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.