ArticleAging2020
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
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In one paragraph
Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Destabilizing the genome as a therapeutic strategy to enhance response to immune checkpoint blockade: a systematic review of clinical trials evidence from solid and hematological tumors.Frontiers in pharmacology · 2023Pooled it
- Contributions of NFKB1 -94insertion/deletion ATTG polymorphism to the susceptibility of gastrointestinal cancers: A meta-analysis.Journal of cellular and molecular medicine · 2021Pooled it
- Closing the gap in aging science: unlocking the potential of nanoparticles in senescence therapy.Biogerontology · 2026Review
- Targeting MYCN Degradation by HLB-0532259 Induces Senescence in Retinoblastoma.Investigative ophthalmology & visual science · 2026Article
- A spatial multi-omics atlas of immunosenescence reveals germinal-center B cell dysfunction in human lymph nodes.Cell press blue · 2026Article
- Expression of Senescence and Osteoporosis-Associated microRNAs in Human Bone and Their Correlations With Clinical Parameters of Osteoporotic Patients.Physiological research · 2026Article
- Molecular mechanisms and recent advances in cellular senescence.Cell & bioscience · 2026Review
- DataXflowGen for GenAI-driven model generation.Scientific reports · 2026Article
- Cellular Senescence Triggered by Food and Environmental Genotoxins.International journal of molecular sciences · 2026Review
- Oxidative Stress-Induced DNA Damage Response Pathways in Aortic Disease: Implications for Inflammation and Vascular Degeneration.International journal of molecular sciences · 2026Review
- The Dual Role of Extracellular Vesicles in Aging and Age-Related Diseases: Pathophysiology and Therapeutic Potential.International journal of nanomedicine · 2026Review
- The inflammatory clock: how cGAS-STING ticks in the aging ovary.Frontiers in cell and developmental biology · 2026Review
- A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linking Ferroptosis to Mitochondrial Dysfunction in Epilepsy.Journal of inflammation research · 2026Article
- Senescence-associated secretory phenotype: the "pathogenic" factor driving orthopedic degenerative diseases and its regulation.Frontiers in aging · 2026Review
- Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives.Bioactive materials · 2025Review
- Activation of cGAS-STING signaling in senescent cells promotes the aging process by remodeling the functions of the immune system.Biogerontology · 2025Review
- The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy.Molecular cancer · 2025Review
- Impact of the ATM/Chk2 pathway and cell cycle phase on radiation-induced senescence in A549 human lung cancer cells.Biomedical reports · 2025Article
- Diversity of oxidative stress and senescence phenotypes induced by chemotherapeutic agents in HUVECs.Scientific reports · 2025Article
- Alzheimer's Disease: From Molecular Mechanisms to Promising Therapeutic Strategies.International journal of molecular sciences · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 7 institutions in 2 countries.
Jing ZhaoDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Lei ZhangDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Aiping LuDepartment of Orthopaedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Yingchao HanDepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Debora ColangeloDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Christina BukataDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Alex ScibettaDepartment of Orthopaedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Matthew J YousefzadehDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Xuesen LiDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Aditi U GurkarDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Sara J McGowanDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Luise AngeliniDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Ryan O'KellyDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Hongshuai LiDepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Lana CorboDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Tokio SanoDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Heather NickDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Enrico PolaDepartment of Orthopaedic Surgery, Catholic University of Rome School of Medicine, "A. Gemelli" University Hospital, Roma, Italy.
Smitha P S PillaDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Warren C LadigesDepartment of Comparative Medicine, University of Washington, Seattle, WA 98195, USA.
Nam VoDepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Johnny HuardDepartment of Orthopaedic Surgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Laura J NiedernhoferDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Paul D RobbinsDepartment of Molecular Medicine and the Center on Aging, Scripps Research, Jupiter, FL 33458, USA.
Scripps Research Institute · USUniversity of Minnesota · USUniversity of Pittsburgh · USThe University of Texas Health Science Center at Houston · USUniversity of Washington · USAgostino Gemelli University Polyclinic · ITSteadman Philippon Research Institute · US
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MVARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5MPROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2MUsing the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4MThe role of cellular senescence in intervertebral disc agingR01AG044376 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VO, NAM V · 2013 to 2017
$1.5MModulators of DNA damage associated nucleo-mitochondrial communication in agingR00AG049126 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GURKAR, ADITI U · 2017 to 2019
$835kImmune cells as a driver of cell non-autonomous agingR56AG059676 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2018 to 2018
$385kNIA NIH HHS P01 AG043376NIA NIH HHS P01 AG062413NIA NIH HHS P30 AG024827NIA NIH HHS R00 AG049126NIA NIH HHS R01 AG044376NIA NIH HHS R01 AG063543NIA NIH HHS R56 AG059676NIA NIH HHS U19 AG056278
Abstract
NF-κB is a transcription factor activated in response to inflammatory, genotoxic and oxidative stress and important for driving senescence and aging. Ataxia-telangiectasia mutated (ATM) kinase, a core component of DNA damage response signaling, activates NF-κB in response to genotoxic and oxidative stress via post-translational modifications. Here we demonstrate that ATM is activated in senescent cells in culture and murine tissues from
Indexed as
AgingAnimalsAtaxia Telangiectasia Mutated ProteinsCells, CulturedCellular SenescenceDNA-Binding ProteinsDNA DamageEndonucleasesMice, Inbred C57BLMice, KnockoutNF-kappa BStem CellsAtaxia Telangiectasia Mutated ProteinsDNA-Binding ProteinsEndonucleasesErcc1 protein, mouseNF-kappa BagingATMcellular senescenceDNA damage responseNF-κB
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.