Evidence map›Paper›PMID 32201327›Full record

ArticleNeuroImage2020

Separating dopamine D

Kelly Smart, Jean-Dominique Gallezot, Nabeel Nabulsi, David Labaree, Ming-Qiang Zheng, Yiyun Huang, Richard E Carson, Ansel T Hillmer, Patrick D Worhunsky

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05105542 (Muscarinic M1 Receptor Availability and Cognition in Schizophrenia), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05105542 phase1completednot on this mapstarted 2021, after this paper: background citation

Muscarinic M1 Receptor Availability and Cognition in Schizophrenia

TypeinterventionalSponsorYale UniversityRan2021 to 2023Enrolled18ConditionsSchizophrenia, Schizoaffective Disorder, HealthyArms11C-EMO - A Novel PET Radiotracer for Muscarinic M1 Receptor, PET Scan
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Continuous infusion [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Review
  4. Molecular connectivity studies in neurotransmission: a scoping review.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  5. Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kelly SmartYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Jean-Dominique GallezotYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Nabeel NabulsiYale PET Center, Yale School of Medicine, New Haven, CT, USA.
David LabareeYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Ming-Qiang ZhengYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Yiyun HuangYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Richard E CarsonYale PET Center, Yale School of Medicine, New Haven, CT, USA.
Ansel T HillmerYale PET Center, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. Electronic address: ansel.hillmer@yale.edu.
Patrick D WorhunskyDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA. Electronic address: patrick.worhunsky@yale.edu.
Yale Cancer Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Investigation of neurofunctional reorganization in cocaine addiction using mGluR5 PET and fMRIK01DA042998 · NIDA · YALE UNIVERSITY · PI WORHUNSKY, PATRICK D · 2017 to 2021
$900k
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
Imaging the Opioid Response to Cannabis SmokingR03DA047588 · NIDA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2019 to 2019
$251k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIDA NIH HHS K01 DA042998NIDA NIH HHS R03 DA047588
6 · The paper itself

Abstract

Development of medications selective for dopamine D

Indexed as

AdultBinding, CompetitiveBrainCarbon RadioisotopesDopamine AntagonistsHumansImage Processing, Computer-AssistedMalePositron-Emission TomographyRadiopharmaceuticalsReceptors, Dopamine D2Receptors, Dopamine D3Carbon RadioisotopesDopamine AntagonistsRadiopharmaceuticalsReceptors, Dopamine D2Receptors, Dopamine D3D(3) receptorsDopamineIndependent component analysisPositron emission tomographyReceptor occupancy

Identifiers

PMID32201327
PMCPMC7263955
OpenAlexW3011103225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.