ArticleNeuroscience2020
Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice.
Article in Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Pain Fluctuations of Women with Subacute Herpetic Neuralgia During Local Methylcobalamin in Combination with Lidocaine Treatment: A Single-Blinded Randomized Controlled Trial.Journal of pain research · 2023Trial
- Nociceptor circadian clock genes control excitability and pain perception in mice in a sex- and time-dependent manner.Nature communications · 2026Article
- Propofol treatment correlates with changes in pain sensitivity and thalamocortical glutamate/GABA balance in sleep-deprived mice.Journal of anesthesia and translational medicine · 2026Article
- Mechanisms and clinical application of photobiomodulation in pain therapy: a mini review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Exposure to Artificial Light at Night Alters Ultradian Rhythms in Endothelial Function.Journal of vascular research · 2025Article
- Sleep and circadian rhythm disturbances as risk and progression factors for multiple chronic overlapping pain conditions: a protocol for a longitudinal study.Pain reports · 2024Article
- Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice.Experimental neurology · 2024Article
- Looking for a Beam of Light to Heal Chronic Pain.Journal of pain research · 2024Review
- Medium- and Long-Term Effects of Insomnia Severity and Circadian Preference on Pain and Emotional Distress Among Individuals With Chronic Pain.The journal of pain · 2023Article
- Acute exposure to artificial light at night alters hippocampal vascular structure in mice.iScience · 2023Article
- The disruptive relationship among circadian rhythms, pain, and opioids.Frontiers in neuroscience · 2023Review
- Dim artificial light at night alters immediate early gene expression throughout the avian brain.Frontiers in neuroscience · 2023Article
- Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response.International journal of molecular sciences · 2022Review
- Light at night disrupts biological clocks, calendars, and immune function.Seminars in immunopathology · 2022Review
- Circadian rhythms and pain.Neuroscience and biobehavioral reviews · 2021Review
- Mechanisms and Pathways of Pain Photobiomodulation: A Narrative Review.The journal of pain · 2021Review
- Implications of Disrupted Circadian Rhythms on Pain.Journal of psychiatry and brain science · 2021Article
- Article
- Differential Effects of Constant Light and Dim Light at Night on the Circadian Control of Metabolism and Behavior.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The growing presence of artificial lighting across the globe presents a number of challenges to human and ecological health despite its societal benefits. Exposure to artificial light at night, a seemingly innocuous aspect of modern life, disrupts behavior and physiological functions. Specifically, light at night induces neuroinflammation, which is implicated in neuropathic and nociceptive pain states, including hyperalgesia and allodynia. Because of its influence on neuroinflammation, we investigated the effects of dim light at night exposure on pain responsiveness in male mice. In this study, mice exposed to four days of dim (5 lux) light at night exhibited cold hyperalgesia. Further, after 28 days of exposure, mice exhibited both cold hyperalgesia and mechanical allodynia. No heat/hot hyperalgesia was observed in this experiment. Altered nociception in mice exposed to dim light at night was concurrent with upregulated interleukin-6 and nerve growth factor mRNA expression in the medulla and elevated μ-opioid receptor mRNA expression in the periaqueductal gray region of the brain. The current results support the relationship between disrupted circadian rhythms and altered pain sensitivity. In summary, we observed that dim light at night induces cold hyperalgesia and mechanical allodynia, potentially through elevated neuroinflammation and dysregulation of the endogenous opioid system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.