ArticleJournal of autoimmunity2020
Gene expression profiling of epithelium-associated FcRL4
Open access · hybridAbstract read
In one paragraph
Article in Journal of autoimmunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Intraepithelial lymphocytes in human oral diseases.Frontiers in immunology · 2025Pooled it
- Elevated CXCL13 in primary Sjögren's syndrome and its correlation with disease activity: a systematic review and meta-analysis.Clinical rheumatology · 2022Pooled it
- Composition and regulation of the immune microenvironment of salivary gland in Sjögren's syndrome.Frontiers in immunology · 2022Pooled it
- Efficacy and safety of remibrutinib, a selective potent oral BTK inhibitor, in Sjögren's syndrome: results from a randomised, double-blind, placebo-controlled phase 2 trial.Annals of the rheumatic diseases · 2024Trial
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Nature communications · 2026Article
- Molecular Insights into Oral Manifestations in Sjögren's Disease.International journal of molecular sciences · 2026Review
- The landscape of B and plasma cells in breast cancer: insights from single-cell and spatial transcriptomics.NPJ breast cancer · 2026Article
- IL-36 mediates immune activation in Sjögren's disease and may represent a novel biomarker of disease.Journal of leukocyte biology · 2026Article
- Tissue-Specific Expansion of Age-Associated B Cells via IFN-γ and IL-21 Within Salivary Glands in Sjögren Disease.Journal of immunology research · 2026Article
- Spatiotemporal orchestration of the salivary gland immune microenvironment in Sjögren's disease: a multidimensional framework of epithelial licensing, lymphoid neogenesis, and stromal remodeling.Frontiers in immunology · 2026Review
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Research square · 2025Article
- Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes.JCI insight · 2025Article
- Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren's-like disease in aging mice.GeroScience · 2024Article
- Double-negative B cells and DNASE1L3 colocalise with microbiota in gut-associated lymphoid tissue.Nature communications · 2024Article
- Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease.Communications biology · 2024Article
- Identification of ferroptosis-related diagnostic markers in primary Sjögren's syndrome based on machine learning.Medicina oral, patologia oral y cirugia bucal · 2024Article
- Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity.Trends in immunology · 2024Review
- Advances in cellular and molecular pathways of salivary gland damage in Sjögren's syndrome.Frontiers in immunology · 2024Review
- Molecular pathology assists the diagnosis of lymphoepithelial sialadenitis, Sjögren's syndrome and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue.Journal of dental sciences · 2024Article
- The role of cytokines from salivary gland epithelial cells in the immunopathology of Sjögren's syndrome.Frontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 3 countries.
Gwenny M VerstappenDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands. Electronic address: G.M.P.J.Verstappen@umcg.nl.
John A IceGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Hendrika BootsmaDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands.
Sarah PringleDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands.
Erlin A HaackeDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, the Netherlands.
Kim de LangeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Gerben B van der VriesDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Peter HickeyThe Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia; Department of Medical Biology, University of Melbourne, Melbourne, VIC, 3010, Australia.
Arjan VissinkDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Frederik K L SpijkervetDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, the Netherlands.
Christopher J LessardGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Frans G M KroeseDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, the Netherlands.
University Medical Center Groningen · NLOklahoma Medical Research Foundation · USThe University of Melbourne · AU
Funding
Transancestral fine mapping and functional dissection of autophagy-related SLE risk lociR01AR071410 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LESSARD, CHRISTOPHER J, TSAO, BETTY P · 2018 to 2022
$3.5MFunctional Evaluation of Established Sjogren's Syndrome Immune Response LociR01AR065953 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI LESSARD, CHRISTOPHER J · 2015 to 2018
$2.1MNIAMS NIH HHS R01 AR065953NIAMS NIH HHS R01 AR071410
Abstract
In primary Sjögren's syndrome (pSS), FcRL4
Indexed as
Gene Expression ProfilingTranscriptomeAgedBiomarkersB-LymphocytesDisease SusceptibilityEpitheliumFemaleGene Expression RegulationHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedReceptors, FcSalivary GlandsBiomarkersFCRL4 protein, humanReceptors, FcAutoimmunityB lymphocytesEpitheliumMALT lymphomaRNA sequencingSalivary glandSjögren's syndrome
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.