ArticleSchizophrenia research2020
Clarifying the direction of impact of negative symptoms and neurocognition on prospective work functioning in psychosis: A 20-year longitudinal study.
Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Understanding the Mechanisms of Cognitive Remediation on Recovery in People With Early Psychosis: A Mediation and Moderation Analysis.Schizophrenia bulletin · 2024Trial
- Efficacy and Safety of Roluperidone for the Treatment of Negative Symptoms of Schizophrenia.Schizophrenia bulletin · 2022Trial
- The Role of Defeatist Performance Beliefs in State Fluctuations of Negative Symptoms in Schizophrenia Measured in Daily Life via Ecological Momentary Assessment.Schizophrenia bulletin · 2024Article
- Exploring parenthood in first episode of psychosis: the potential role of the offspring in the outcome of women.Archives of women's mental health · 2024Article
- 20-year neurocognitive development following a schizophrenia spectrum disorder and associations with symptom severity and functional outcomes.Psychological medicine · 2024Article
- Negative symptoms and social cognition as mediators of the relationship between neurocognition and functional outcome in schizophrenia.Frontiers in psychiatry · 2024Article
- Development and Validation of the Negative Symptom Inventory-Psychosis Risk.Schizophrenia bulletin · 2023Article
- Ecological Momentary Assessment Of State Fluctuations In Mindfulness And Symptoms In Psychotic Disorders.Journal of contextual behavioral science · 2023Article
- Negative Symptom Inventory-Self-Report (NSI-SR): Initial development and validation.Schizophrenia research · 2023Article
- Negative symptoms in schizophrenia differ across environmental contexts in daily life.Journal of psychiatric research · 2023Article
- Activation of Internal Correctness Monitoring Circuitry in Youths With Psychosis Spectrum Symptoms.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Mediators of quality of life change in people with severe psychotic disorders treated in integrated care: ACCESS II study.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Identifying subgroups based on self-assessment of ability in patients with schizophrenia and its relationship with vocational outcomes.Hong Kong journal of occupational therapy : HKJOT · 2022Article
- Article
- Cognitive, community functioning and clinical correlates of the Clinical Assessment Interview for Negative Symptoms (CAINS) in psychotic disorders.European archives of psychiatry and clinical neuroscience · 2021Article
- A word is worth a thousand pictures: A 20-year comparative analysis of aberrant abstraction in schizophrenia, affective psychosis, and non-psychotic depression.Schizophrenia research · 2021Article
- Association of Negative Symptoms of Schizophrenia Assessed by the BNSS and SNS Scales With Neuropsychological Performance: A Gender Effect.Frontiers in psychiatry · 2021Article
- Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Both neurocognition and negative symptoms have demonstrated strong links to functional outcomes, such as work functioning, among those with severe mental illness (SMI). Prior models have suggested that reduced neurocognition 1) precedes or predicts greater negative symptoms and 2) indirectly influences functional outcomes via its impact on negative symptoms. The current study sought to also test a divergent model: whether greater negative symptoms predict reduced neurocognition and indirectly influence work functioning through their impact on neurocognition. Both models were tested using cross-sectional and prospective data spanning 20-years in a sample of 277 people with a SMI with psychotic features. Results showed that both models were supported in cross-sectional analyses. However, in prospective models predicting work functioning, only the models examining the indirect influence of negative symptoms on work functioning (7.5 to up to 20-years later) through neurocognition demonstrated significant mediation (i.e., a significant indirect effect); further, higher negative symptoms significantly predicted lower prospective neurocognition, while lower neurocognition did not significantly predict greater prospective negative symptoms. Although cross-sectional data were consistent with prior models, our prospective models offered greater support for a putative causal pathway running from negative symptoms to neurocognition-rather than the reverse-to work functioning. Findings have implications for mechanisms contributing to longitudinal work functioning and suggest that targeting negative symptoms prior to neurocognition could be more beneficial for long-term work outcomes.
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Registered trials
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