ArticleBiomedical journal2020
Novel human models for elucidating mechanisms of rate-sensitive H-reflex depression.
Article in Biomedical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis.PloS one · 2020Pooled it
- Soleus H-reflex size versus stimulation rate in the presence of background muscle activity: a methodological study.Experimental brain research · 2025Article
- Rate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy.Diabetes & metabolism journal · 2024Review
- Effects of ankle continuous passive motion on soleus hypertonia in individuals with cerebral palsy: A case series.Biomedical journal · 2022Article
- Optimal Utility of H-Reflex RDD as a Biomarker of Spinal Disinhibition in Painful and Painless Diabetic Neuropathy.Diagnostics (Basel, Switzerland) · 2021Article
- Evidence-based practice utilization and associated factors among nurses working in Amhara Region Referral Hospitals, Ethiopia.PloS one · 2021Article
- Tumour travel tours - Why circulating cancer cells value company.Biomedical journal · 2020Article
- Article
- Augmented and prematurely occurring H-reflex recovery curve shows enhanced spinal network excitability in ALS patients when employing the double stimulation paradigm.Frontiers in neurologyArticle
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThis study used novel human neurophysiologic models to investigate whether the mechanism of rate-sensitive H-reflex depression lies in the pre-synaptic or post-synaptic locus in humans. We hypothesized that pre-synaptic inhibition would suppress Ia afferents and H-reflexes without suppressing alpha motor neurons or motor evoked potentials (MEPs). In contrast, post-synaptic inhibition would suppress alpha motor neurons, thereby reducing H-reflexes and MEPs.
methodsWe recruited 23 healthy adults with typical rate-sensitive H-reflex depression, 2 participants with acute sensory-impaired spinal cord injury (SCI) (to rule out influence of sensory stimulation on supra-spinal excitability), and an atypical cohort of 5 healthy adults without rate-sensitive depression. After a single electrical stimulation to the tibial nerve, we administered either a testing H-reflex or a testing MEP at 50-5000 ms intervals.
resultsTesting MEPs were not diminished in healthy subjects with or without typical rate-sensitive H-reflex depression, or in subjects with sensory-impaired SCI. MEP responses were similar in healthy subjects with versus without rate-sensitive H-reflex depression.
conclusionsResults from these novel in vivo human models support a pre-synaptic locus of rate-sensitive H-reflex depression for the first time in humans. Spinal reflex excitability can be modulated separately from descending corticospinal influence. Each represents a potential target for neuromodulatory intervention.
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