Evidence map›Paper›PMID 32200795›Full record

ArticleMolecular cell2020

Splice or Die: When MYC Is Driving, Transcription Needs NUAK1 to Avoid Fatal Pileups.

Robert P Fisher

Abstract readComment
In one paragraph

Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Robert P FisherDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: robert.fisher@mssm.edu.

Funding

Cyclin-dependent kinase control of cell-division and transcription cyclesR35GM127289 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROBERT P FISHER · 2018 to 2026
$4.4M
NIGMS NIH HHS R35 GM127289
6 · The paper itself

Abstract

In this issue of Molecular Cell, Cossa et al. (2020) uncover the basis for a dependency of tumor cells with deregulated MYC on the kinase NUAK1, which acts through PP1 and PNUTS to ensure that splicing keeps up with MYC-driven transcription.

Indexed as

SpliceosomesProtein Phosphatase 1Protein Phosphatase 1

Identifiers

PMID32200795
PMCPMC7910809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.