ArticleJournal of veterinary internal medicine2020
Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Pre-anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review.The Journal of small animal practice · 2026Review
- Validation of deep learning enabled software MetronMind to measure vertebral heart size and vertebral left atrial size in dogs.PloS one · 2026Article
- Article
- Respiratory rate and breathing pattern in dogs and cats in intensive care units and the value of camera surveillance.The Journal of small animal practice · 2025Article
- Sodium-glucose co-transporter 2 inhibitors: Prospects for canine myxomatous mitral valve disease and finding the "right drug" and the "right dose" for dogs.The Journal of veterinary medical science · 2025Review
- Vertebral Heart Score and Vertebral Left Atrial Size as Radiographic Measurements for Cardiac Size in Dogs-A Literature Review.Animals : an open access journal from MDPI · 2025Review
- Resting heArt and respIratory rates in dogs in their natural environment: new insights from a long-term, international, prospective study in a COhort of 703 dogs using a biometric device for LongitudinaL non-invasive cARdiorespiratory monitoring (the AI-COLLAR study).Frontiers in veterinary science · 2025Article
- Machine Learning Techniques for Canine Myxomatous Mitral Valve Disease Classification: Integrating Anamnesis, Quality of Life Survey, and Physical Examination.Veterinary sciences · 2024Article
- Analysis of Poincaré plot derived from 5-min electrocardiography in dogs with myxomatous mitral valve disease.The veterinary quarterly · 2023Article
- Evaluation of the association between electrocardiogram parameters and left cardiac remodeling in dogs with myxomatous mitral valve disease.Veterinary world · 2022Article
- Accuracy of history, physical examination, cardiac biomarkers, and biochemical variables in identifying dogs with stage B2 degenerative mitral valve disease.Journal of veterinary internal medicine · 2021Article
- Utility of point-of-care lung ultrasound for monitoring cardiogenic pulmonary edema in dogs.Journal of veterinary internal medicine · 2021Article
- Protective effects of omega-3 fatty acids in dogs with myxomatous mitral valve disease stages B2 and C.PloS one · 2021Article
- Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study.Journal of veterinary internal medicine · 2020Article
- Preoperative Prediction Models for 30-Day All-Cause Mortality After Mitral Valve Repair in Dogs: A Single-Center Retrospective Cohort Study.Journal of veterinary internal medicineArticle
- Assessment of heart rate turbulence in dogs with myxomatous mitral valve disease.Open veterinary journalArticle
- Radiographic lung congestion scores in dogs with acute congestive heart failure caused by myxomatous mitral valve disease.Journal of veterinary internal medicineArticle
- Risk Stratification Using Mitral INsufficiency Echocardiographic Score 2 in Dogs With Preclinical Mitral Valve Disease.Journal of veterinary internal medicineArticle
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Authors and funding
40 authors at 20 institutions in 11 countries.
Funding
Abstract
backgroundThe Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF).
objectivesTo describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF. ANIMALS: One hundred and thirty-five, and 73 dogs that did or did not develop CHF, respectively. MATERIALS AND
methodsThe following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home-measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points.
resultsThe most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF. CONCLUSIONS AND CLINICAL IMPORTANCE: Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.