ArticleHeadache2020
Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study.
Article in Headache, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 7 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Chronic Pain and the Risk of Dementia: A Systematic Review and Meta-Analysis.Current pain and headache reports · 2026Pooled it
- Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization.Brain and behavior · 2026Pooled it
- Migraine is a risk factor for dementia: a systematic review and meta-analysis of cohort studies.The journal of headache and pain · 2025Pooled it
- Is headache a risk factor for dementia? A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Association between migraine and cognitive impairment.The journal of headache and pain · 2022Pooled it
- Migraine and the risk of dementia: a meta-analysis and systematic review.Aging clinical and experimental research · 2022Pooled it
- Association of Headache Disorders and the Risk of Dementia: Meta-Analysis of Cohort Studies.Frontiers in aging neuroscience · 2022Pooled it
- Migraine and Cardiovascular Risk: A Scoping Review of Vascular Outcomes, Risk Assessment, and Endothelial Dysfunction.Life (Basel, Switzerland) · 2026Review
- Headache associated with adverse cognitive trajectories in Chinese aging cohort: a group-based trajectory modeling study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Genetic evidence for causal association between migraine and dementia: a mendelian randomization study.BMC medical genomics · 2024Article
- Association between chronic pain and dementia: a systematic review and meta-analysis.European journal of ageing · 2024Review
- Independent causal effect of migraines on Alzheimer's disease risk: a multivariate Mendelian randomization study.Frontiers in neurology · 2024Article
- Association between migraine and Alzheimer's disease: a nationwide cohort study.Frontiers in aging neuroscience · 2023Article
- Bibliometric Analysis of Research on Migraine-Stroke Association from 2013 to 2023.Journal of pain research · 2023Article
- Migraine Pharmacological Treatment and Cognitive Impairment: Risks and Benefits.International journal of molecular sciences · 2022Review
- Preventive treatment can reverse cognitive impairment in chronic migraine.The journal of headache and pain · 2022Article
- Increased risk of all-cause, Alzheimer's, and vascular dementia in adults with migraine in Korea: a population-based cohort study.The journal of headache and pain · 2022Article
- The mysterious connection between migraine and dementia: epiphenomenon or causation? Special considerations.Aging clinical and experimental research · 2022Article
- Cognitive Impairment in Primary and Secondary Headache Disorders.Current pain and headache reports · 2022Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveWe aimed to assess the association between migraine headache and incident dementia.
backgroundMigraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with increased risk of dementia. However, it is unknown whether migraine is independently associated with dementia.
methodsHistory of migraine was ascertained via questionnaire. Adjudicated cases of dementia were identified using cognitive tests, neuropsychological exams, and clinician review of suspected cases. Incident dementia was identified using adjudicated cases, follow-up calls, and surveillance of hospital and death codes. We assessed hazards of incident dementia by migraine status. Sex differences were also examined and stratified results were presented.
resultsAnalysis included 12,495 White and African American participants ages 51-70 with a median follow-up time of 21 years. Prevalence of dementia was 18.5% (1821/9955) among those with no migraine history, 15.8% (196/1243) among those with severe non-migraine heading, and 16.7% (233/1397) among migraineurs. There was no association between migraine and incident dementia [hazard ratio: 1.04 (0.91, 1.20)]. There was also no statistically significant interaction between sex and migraine status on risk of dementia.
conclusionDespite evidence of brain abnormalities in migraineurs, there was no association between migraine and incident dementia in this prospective cohort.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.