ArticleInternational ophthalmology2020
Features of cotton wool spots in diabetic retinopathy: a spectral-domain optical coherence tomography angiography study.
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Retinal manifestations in patients with SARS-CoV-2 infection and pathogenetic implications: a systematic review.International ophthalmology · 2022Pooled it
- Retinal Arterial Vasospasm in Retinal Vein Occlusion and Its Association with Aqueous Humor Endothelin-1.Ophthalmology and therapy · 2026Article
- Longitudinal evaluation of cotton wool spot following rapid glycemic improvement using wide-field multimodal imaging.American journal of ophthalmology case reports · 2025Article
- Genetic context modulates aging and degeneration in the murine retina.Molecular neurodegeneration · 2025Article
- Genetic context modulates aging and degeneration in the murine retina.bioRxiv : the preprint server for biology · 2024Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy.Frontiers in medicine · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the features of cotton wool spots (CWSs) in diabetic retinopathy (DR) by using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT angiography).
methodsWe retrospectively studied patients with DR who presented CWSs and had been imaged by SD-OCT angiography. The retinal layer localisation and dimensions of the CWSs were assessed on SD-OCT, while the decorrelation signal generated by the CWSs and the vascular density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus around the CWSs and in the macula were assessed on OCT angiography.
resultsA total of 87 eyes of 57 DR patients were included. All CWSs were located in the retinal nerve fibre layer and exhibited a decorrelation signal on OCT angiography. In 68 eyes (78.1%), hyporeflective cavities appearing as cysts in the CWS were noted, especially when were peripheral and large (P < 0.0001). The thickness averaged 211.8 ± 80.02 mm and was positively influenced by recent diabetes history, glycaemic dysregulation, posterior pole localisation and a high VD of the SCP around the CWS, while the surface area averaged 0.33 ± 0.24 mm
conclusionThe features of CWSs are influenced by systemic factors, such as history and severity of diabetes, in association with local factors, such as localisation and retinal ischaemia. The peripheral localisation of ischaemia confirms the hypothesis that CWSs are sentinel lesions.
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