ArticleiScience2020
A Universal Strategy to Construct Lanthanide-Doped Nanoparticles-Based Activable NIR-II Luminescence Probe for Bioimaging.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Enhanced brightness and photostability of dye-sensitized Nd-doped rare earth nanocomposite for in vivo NIR-IIb vascular and orthotopic tumor imaging.Journal of nanobiotechnology · 2025Article
- Fluorescent Tracers forFrontiers in pharmacology · 2022Review
- Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases.Biosensors · 2021Review
- Review
- Near-Infrared Inorganic Nanomaterials for Precise Diagnosis and Therapy.Frontiers in bioengineering and biotechnology · 2021Review
- Synthesis and Biomedical Applications of Lanthanides-Doped Persistent Luminescence Phosphors With NIR Emissions.Frontiers in chemistry · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lanthanide-doped nanoparticles (LnNPs) have gained increasing attention recently for bioimaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) because of their excellent photophysical properties, but the construction of LnNPs-based activable probe responding to specific targets remains a challenge. Herein, we proposed an uncomplicated and universal strategy to fabricate LnNPs-based NIR-II probes by target-triggered dye-sensitization process. The dye acts as both the recognition motif of the target and a potential antenna for LnNPs, which can be activated by the target to sensitize the NIR-II luminescence of LnNPs. A proof-of-concept probe for glutathione (GSH) was constructed to validate this approach. It was able to track the fluctuation of GSH level in liver and lymphatic drainage and provide clear images with high contrast and resolution in vivo. This strategy can be generalized to construct NIR-II probes for various analytes by simply changing the recognition motif of the dye, greatly promoting the application of LnNPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.