SynthesisGastroenterology2020
Prevalence and Clinical Features of Sessile Serrated Polyps: A Systematic Review.
Synthesis in Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Quality indicators for colonoscopy.Gastrointestinal endoscopy · 2024Guideline
- Association BetweenFrontiers in medicine · 2021Pooled it
- Determinants of high sessile serrated lesion detection: Role of faecal occult blood test and colonoscopy quality indicators.World journal of gastrointestinal endoscopy · 2025Trial
- Evaluating Intermittent Dosing of Aspirin for Colorectal Cancer Chemoprevention.Cancer prevention research (Philadelphia, Pa.) · 2025Trial
- Effect of an E-learning resource on endoscopists' proximal serrated polyp detection rate: a randomized controlled trial.Endoscopy · 2024Trial
- Bridging the Precancerous Gap in Colorectal Cancer Through AI-Enhanced Liquid Biopsy, Endoscopy, and Digital Pathology.Cancers · 2026Review
- Management of Colorectal Sessile Serrated Lesions in Elderly Patients.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- CRC-SPIN version 3.0: an updated policy model for colorectal cancer screening that includes the serrated pathway.Journal of the National Cancer Institute · 2026Article
- Evaluation of serrated lesion detection using different indicators: a single-centre, community-based, retrospective cohort study.BMJ open gastroenterology · 2026Article
- Higher Sessile Serrated Lesion Detection Rates Calculated Using All Examinations Are Associated With Lower Risk for Postcolonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry.Clinical and translational gastroenterology · 2026Article
- Artificial intelligence and digital transformation of gastroenterology and hepatology: A critical review of clinical applications and future challenges.World journal of hepatology · 2026Review
- Pragmatic Implementation Study of a Computer-Aided Detection Device on Colonoscopy Outcomes at a Trainee-Dominated Academic County Hospital.Digestive diseases and sciences · 2026Article
- Colonoscopy Quality and Strategies for Improvement.Gut and liver · 2026Review
- Efficacy and cost-effectiveness of extending risk-stratified colorectal cancer screening: evidence from China's first province-wide program.International journal of surgery (London, England) · 2026Article
- A novel cloud-based artificial intelligence for real-time detection of colorectal neoplasia - a randomized controlled trial (EAGLE).NPJ digital medicine · 2025Article
- Benchmarking sessile serrated lesion detection in colonoscopy: individual endoscopist performance has greater impact than specialty training - a retrospective analysis of 12,064 procedures.BMC gastroenterology · 2025Article
- Clinicopathological Characteristics and Synchronous Lesions in Colorectal Cancer: A Single-Center Retrospective Colonoscopy Study.Journal of clinical medicine · 2025Article
- Management of Malignant Colon Polyps.Clinics in colon and rectal surgery · 2025Review
- Serrated polyps in colorectal cancer prevention: prevalence, characteristics and clinical insights from a large retrospective cohort study.BMC gastroenterology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
BACKGROUND &
aimsSessile serrated polyps (SSPs) could account for a substantial proportion of colorectal cancers. We aimed to increase clarity on SSP prevalence and clinical features.
methodsWe performed a systematic review of MEDLINE, Web of Science, Embase, and Cochrane databases for original studies published in English since 2000. We included studies of different populations (United States general or similar), interventions (colonoscopy, autopsy), comparisons (world regions, alternative polyp definitions, adenoma), outcomes (prevalence, clinical features), and study designs (cross-sectional). Random-effects regression was used for meta-analysis where possible.
resultsWe identified 74 relevant colonoscopy studies. SSP prevalence varied by world region, from 2.6% in Asia (95% confidence interval [CI], 0-5.9) to 10.5% in Australia (95% CI, 2.8-18.2). Prevalence values did not differ significantly between the United States and Europe (P = .51); the pooled prevalence was 4.6% (95% CI, 3.4-5.8), and SSPs accounted for 9.4% of polyps with malignant potential (95% CI, 6.6-12.3). The mean prevalence was higher when assessed through high-performance examinations (9.1%; 95% CI, 4.0-14.2; P = .04) and with an alternative definition of clinically relevant serrated polyps (12.3%; 95% CI, 9.3-15.4; P < .001). Increases in prevalence with age were not statistically significant, and prevalence did not differ significantly by sex. Compared with adenomas, a higher proportion of SSPs were solitary (69.0%; 95% CI, 45.9-92.1; P = .08), with diameters of 10 mm or more (19.3%; 95% CI, 12.4-26.2; P = .13) and were proximal (71.5%; 95% CI, 63.5-79.5; P = .008). The mean ages for detection of SSP without dysplasia, with any or low-grade dysplasia, and with high-grade dysplasia were 60.8 years, 65.6 years, and 70.2 years, respectively. The range for proportions of SSPs with dysplasia was 3.7%-42.9% across studies, possibly reflecting different study populations.
conclusionsIn a systematic review, we found that SSPs are relatively uncommon compared with adenoma. More research is needed on appropriate diagnostic criteria, variations in detection, and long-term risk.
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