ArticleJACC. Cardiovascular imaging2020
Prognostic Value of Myocardial Extracellular Volume Fraction and T2-mapping in Heart Transplant Patients.
Article in JACC. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Diagnostic and Prognostic Value of Cardiac Magnetic Resonance for Cardiotoxicity Caused by Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2025Pooled it
- Association Between HIV Infection Duration and Left Ventricular Concentric Remodeling and Myocardial Fibrosis: A Cross-Sectional Study Using Cardiac MRI.Journal of magnetic resonance imaging : JMRI · 2026Article
- Role of Cardiovascular Magnetic Resonance in Post-Heart Transplant Surveillance: Integrating Evidence with Prospective Cohort Data.Journal of personalized medicine · 2026Article
- Multimodal Cardiac Imaging of Immune-Mediated Complications Post Heart Transplantation: A Contemporary Review.Journal of the American Heart Association · 2026Review
- Cardiac Magnetic Resonance Imaging in Pediatric Heart Transplant Recipients: Correlation with Cardiopulmonary Exercise Testing.Pediatric cardiology · 2025Article
- Clinical determinants and biomarkers associated with cardiac fibrosis after heart transplantation as assessed by magnetic resonance: Size matters.International journal of cardiology. Heart & vasculature · 2024Article
- Charting the Unseen: How Non-Invasive Imaging Could Redefine Cardiovascular Prevention.Journal of cardiovascular development and disease · 2024Review
- Cardiac magnetic resonance evaluation in recipients of hepatitis c virus-infected donor hearts.JHLT open · 2024Article
- Tissue characterization of acute lesions during cardiac magnetic resonance-guided ablation of cavo-tricuspid isthmus-dependent atrial flutter: a feasibility study.European heart journal. Cardiovascular Imaging · 2024Article
- Cardiac Allograft Vasculopathy: Challenges and Advances in Invasive and Non-Invasive Diagnostic Modalities.Journal of cardiovascular development and disease · 2024Review
- Myocardial Tissue Characterization in Patients with Hypertensive Crisis, Positive Troponin, and Unobstructed Coronary Arteries: A Cardiovascular Magnetic Resonance-Based Study.Diagnostics (Basel, Switzerland) · 2023Article
- Chemotherapy-Related Cardiac Dysfunction: Quantitative Cardiac Magnetic Resonance Image Parameters and Their Prognostic Implications.Korean journal of radiology · 2023Article
- Multiparametric cardiovascular magnetic resonance characteristics and dynamic changes in asymptomatic heart-transplanted patients.European radiology · 2023Article
- Potential Prognostic Value of Native T1 in Pulmonary Hypertension Patients.Life (Basel, Switzerland) · 2023Article
- Artificial Intelligence in Cardiovascular CT and MR Imaging.Life (Basel, Switzerland) · 2023Review
- Role of cardiovascular magnetic resonance imaging in COVID-19 recovered patients: A short-term follow-up study.Echocardiography (Mount Kisco, N.Y.) · 2022Article
- Multiphoton microscopy providing pathological-level quantification of myocardial fibrosis in transplanted human heart.Lasers in medical science · 2022Article
- The role of non-invasive imaging modalities in cardiac allograft vasculopathy: an updated focus on current evidences.Heart failure reviews · 2022Review
- Multi-parametric cardiovascular magnetic resonance with regadenoson stress perfusion is safe following pediatric heart transplantation and identifies history of rejection and cardiac allograft vasculopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Article
- Multimodality cardiac imaging in the 21st century: evolution, advances and future opportunities for innovation.The British journal of radiology · 2021Review
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15 authors at 1 institution in 1 country.
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Abstract
objectivesThe purpose of this study was to examine prognostic value of T1- and T2-mapping techniques in heart transplant patients.
backgroundMyocardial characterization using T2 mapping (evaluation of edema/inflammation) and pre- and post-gadolinium contrast T1 mapping (calculation of extracellular volume fraction [ECV] for assessment of interstitial expansion/fibrosis) are emerging modalities that have been investigated in various cardiomyopathies.
methodsA total of 99 heart transplant patients underwent the magnetic resonance imaging (MRI) scans including T1- (n = 90) and T2-mapping (n = 79) techniques. Relevant clinical characteristics, MRI parameters including late gadolinium enhancement (LGE), and invasive hemodynamics were collected. Median clinical follow-up duration after the baseline scan was 2.4 to 3.5 years. Clinical outcomes include cardiac events (cardiac death, myocardial infarction, coronary revascularization, and heart failure hospitalization), noncardiac death and noncardiac hospitalization.
resultsOverall, the global native T1, postcontrast T1, ECV, and T2 were 1,030 ± 56 ms, 458 ± 84 ms, 27 ± 4% and 50 ± 4 ms, respectively. Top-tercile-range ECV (ECV >29%) independently predicted adverse clinical outcomes compared with bottom-tercile-range ECV (ECV <25%) (hazard ratio [HR]: 2.87; 95% confidence interval [CI]: 1.07 to 7.68; p = 0.04) in a multivariable model with left ventricular end-systolic volume and LGE. Higher T2 (T2 ≥50.2 ms) independently predicted adverse clinical outcomes (HR: 3.01; 95% CI: 1.39 to 6.54; p = 0.005) after adjustment for left ventricular ejection fraction, left ventricular end-systolic volume, and LGE. Additionally, higher T2 (T2 ≥50.2 ms) also independently predicted cardiac events (HR: 4.92; CI: 1.60 to 15.14; p = 0.005) in a multivariable model with left ventricular ejection fraction.
conclusionsMRI-derived myocardial ECV and T2 mapping in heart transplant patients were independently associated with cardiac and noncardiac outcomes. Our findings highlight the need for larger prospective studies.
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