Evidence map›Paper›PMID 32199750›Full record

ArticleAdvances in biological regulation2020

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A

Varnavas D Mouchlis, Carol Mu, Renee Hammons, Edward A Dennis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in biological regulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Phospholipases: Where Do We Stand?Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. The mechanism of allosteric regulation of calcium-independent phospholipase AProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Lipoprotein-associated phospholipase AProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Varnavas D MouchlisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093-0601, USA. Electronic address: vmouchlis@gmail.com.
Carol MuDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093-0601, USA.
Renee HammonsDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093-0601, USA.
Edward A DennisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, 92093-0601, USA. Electronic address: edennis@ucsd.edu.
University of California San Diego · US

Funding

ACTION OF LIPOLYTIC ENZYMESR01GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 1985 to 2020
$7.3M
DESIGN OF AMPHIPHILIC PEPTOID ASSEMBLIESF32GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BURKOTH, TIMOTHY S · 2000 to 2002
$75k
NIGMS NIH HHS F32 GM020501NIGMS NIH HHS R01 GM020501
6 · The paper itself

Abstract

Phospholipase A

Indexed as

High-Throughput Screening AssaysBinding SitesFatty Acids, NonesterifiedLipidomicsLysophospholipidsMolecular Docking SimulationMolecular Dynamics SimulationPhospholipase A2 InhibitorsPhospholipases A2Protein BindingProtein Interaction Domains and MotifsProtein Structure, SecondarySmall Molecule LibrariesSubstrate SpecificityUser-Computer InterfaceFatty Acids, NonesterifiedLysophospholipidsPhospholipase A2 InhibitorsPhospholipases A2Small Molecule LibrariesDose-response inhibitionEnzymatic assaysHit compoundsPhospholipase A(2)Virtual screening

Identifiers

PMID32199750
PMCPMC7230010
OpenAlexW3012291920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.