ArticleBiological psychiatry2020
Maternal Effects as Causes of Risk for Obsessive-Compulsive Disorder.
Article in Biological psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- "It Doesn't Matter Where OCD Comes From," or Does It?Current psychiatry reports · 2026Review
- Understanding Sex and Gender Effects on Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Clinical Presentation and Risk Factors.Biological psychiatry global open science · 2026Review
- Pharmacogenomic-guided prescribing and polypharmacy across age groups in obsessive-compulsive disorder: a retrospective study.BMC psychiatry · 2026Article
- Methods for joint genetic prediction of multiple ordinal categorical and continuous traits.Genetics · 2026Article
- Black EquaLity in OCD NeuroGenomics (BELONG): Study Protocol.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Efficacy, management of adverse effects and relapse forms after obsessive-compulsive disorder surgery: The first Egyptian and Arab cohort.Surgical neurology international · 2026Article
- Rare coding variation in OCD implicates shared genes with other psychiatric disorders.medRxiv : the preprint server for health sciences · 2025Article
- Semi-parametric validation of genomic predictions and polygenic risk scores with the Blupf90 software suite.G3 (Bethesda, Md.) · 2025Article
- A Population-Based Multigenerational Family Coaggregation Study of Severe Infections and Obsessive-Compulsive Disorder.Biological psychiatry · 2025Article
- Precision neurodiversity: personalized brain network architecture as a window into cognitive variability.Frontiers in human neuroscience · 2025Review
- Informational Analysis and Prediction of Obsessive-Compulsive Disorder Pathogenesis.Psychiatry investigation · 2024Article
- Potential biomarkers and therapeutic targets for obsessive compulsive disorder: Evidences from clinical studies.Biochemia medica · 2024Review
- Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families.Psychiatry research · 2024Article
- Clinical Advances in Treatment Strategies for Obsessive-compulsive Disorder in Adults.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Review
- Direct additive genetics and maternal effect contribute to the risk of Tourette disorder.Journal of neurology, neurosurgery, and psychiatry · 2023Article
- Communal nesting differentially attenuates the impact of pre-weaning social isolation on behavior in male and female rats during adolescence and adulthood.Frontiers in behavioral neuroscience · 2023Article
- Psychometric properties of the Swedish translation of the Obsessive-Compulsive Inventory-Revised and the population characteristics of the symptom dimensions of OCD.Social psychiatry and psychiatric epidemiology · 2022Article
- The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum.The American journal of psychiatry · 2022Article
- Genetics of obsessive-compulsive disorder.Psychological medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundWhile genetic variation has a known impact on the risk for obsessive-compulsive disorder (OCD), there is also evidence that there are maternal components to this risk. Here, we partitioned sources of variation, including direct genetic and maternal effects, on risk for OCD.
methodsThe study population consisted of 822,843 individuals from the Swedish Medical Birth Register, born in Sweden between January 1, 1982, and December 31, 1990, and followed for a diagnosis of OCD through December 31, 2013. Diagnostic information about OCD was obtained using the Swedish National Patient Register.
resultsA total of 7184 individuals in the birth cohort (0.87%) were diagnosed with OCD. After exploring various generalized linear mixed models to fit the diagnostic data, genetic maternal effects accounted for 7.6% (95% credible interval: 6.9%-8.3%) of the total variance in risk for OCD for the best model, and direct additive genetics accounted for 35% (95% credible interval: 32.3%-36.9%). These findings were robust under alternative models.
conclusionsOur results establish genetic maternal effects as influencing risk for OCD in offspring. We also show that additive genetic effects in OCD are overestimated when maternal effects are not modeled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.