Evidence map›Paper›PMID 32199541›Full record

Trial reportJournal of substance abuse treatment2020

Randomized clinical trial of Cognitive Remediation Therapy with Work Therapy in the early phase of substance use disorder recovery for older Veterans: 12-Month follow-up.

Morris D Bell, Bharath Muppala, Andrea J Weinstein, David Ciosek, Brian Pittman, Ismene Petrakis, Joanna M Fiszdon

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of substance abuse treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Morris D BellDepartment of Psychiatry, Yale University, VA Connecticut Healthcare System, United States of America. Electronic address: Morris.bell@yale.edu.
Bharath MuppalaDepartment of Psychiatry, Yale University, United States of America.
Andrea J WeinsteinDepartment of Psychiatry, Yale University, United States of America.
David CiosekVA Connecticut Healthcare System, United States of America.
Brian PittmanDepartment of Psychiatry, Yale University, United States of America.
Ismene PetrakisDepartment of Psychiatry, Yale University, VA Connecticut Healthcare System, United States of America.
Joanna M FiszdonDepartment of Psychiatry, Yale University, VA Connecticut Healthcare System, United States of America.
Yale University · USVA Connecticut Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse TrR21DA030744 · NIDA · YALE UNIVERSITY · PI BELL, MORRIS D. · 2010 to 2011
$353k
Cognitive Training in the Treatment of Alcohol Use Disorders in Older VeteransI01RX002017 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI BELL, MORRIS D. · 2016 to 2021
–
RR&D Senior Research Career Scientist AwardIK6RX002458 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI MORRIS D. BELL · 2017 to 2026
–
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R21 DA030744RRD VA I01 RX002017RRD VA IK6 RX002458
6 · The paper itself

Abstract

objectiveIn a previous report on a randomized clinical trial of a 3-month program of Cognitive Remediation Therapy (CRT) augmented by Work Therapy (WT) compared with WT alone for older veterans with substance use disorder (SUD), we reported significantly greater improvements at six-month follow-up on neurocognitive outcomes of working memory and executive functions for the CRT + WT condition. However, no difference was found between conditions on SUD outcomes, with both groups showing unusually high levels of abstinence. In this study, we extended follow-up to 12 months to test whether there was an SUD outcome "sleeper effect" from CRT + WT. To better understand the effects of WT, we added a treatment-as-usual (TAU) comparison sample.

methodForty-eight veterans with SUD receiving standard outpatient VA care were randomized into CRT + WT or WT. Clinical Global Impression (CGI) ratings were performed on 43/48 participants with up-to-date medical records. A TAU comparison group (n = 44) with similar demographic and illness characteristics was added to the analysis.

resultsTreatment groups did not differ significantly at 12 months on CGI (p = 0.27), with 77% receiving CRT + WT showing favorable SUD outcomes compared to 62% in WT. Both groups had better CGI outcomes (p < 0.01) compared to the TAU comparison group (27%). Hours of WT participation (r = -0.49, p = 0.001) and hours of CRT (r = -0.45, p = 0.048) were associated with better CGI scores.

conclusionWhile no sleeper effect was found for CRT, a robust effect was strongly supported for WT on SUD outcomes.

Indexed as

Cognitive Behavioral TherapyCognitive RemediationSubstance-Related DisordersVeteransFollow-Up StudiesHumansTreatment OutcomeClinical Global ImpressionCognitive remediationOlder veteransSubstance use disorderWork therapy

Identifiers

PMID32199541
PMCPMC7089868
OpenAlexW3003819744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.