ArticlePsychoneuroendocrinology2020
Associations of waking cortisol with DHEA and testosterone across the pubertal transition: Effects of threat-related early life stress.
Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
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- Epigenetic impact of a 1-week intensive multimodal group program for adolescents with multiple adverse childhood experiences.Scientific reports · 2022Trial
- Heightened sensitivity to the caregiving environment during adolescence: implications for recovery following early-life adversity.Journal of child psychology and psychiatry, and allied disciplines · 2021Trial
- Trajectories of internalizing problems during and after the COVID-19 pandemic: The effects of sex and early life stress.Journal of affective disorders · 2026Article
- Characteristics of non-suicidal self-injury and its associations with thyroid and sex hormones in adolescents with major depressive disorder and bipolar disorder.BMC psychiatry · 2026Article
- Continuous Versus Grouping Approaches to Resilience: Predicting Mental Health Following Adversity in Two Longitudinal Datasets.JAACAP open · 2026Article
- Mixed evidence for stress effects on cortisol-testosterone coupling in Syrian refugee and Jordanian non-refugee adolescents.Psychoneuroendocrinology · 2026Article
- Maternal History of Child Maltreatment Predicts Dysregulated Offspring Stress Response System Functioning.Child maltreatment · 2025Article
- Pollution burden and trajectories of pubertal development: Implications for sleep disturbances and depressive symptoms.Psychoneuroendocrinology · 2025Article
- Positive Cortisol-Testosterone Hormonal Coupling Among Adolescents in Argentina and Jordan.American journal of biological anthropology · 2025Article
- Psychoneuroendocrine stress response in female and male youth with major depressive disorder.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- The effects of the COVID-19 pandemic on neurobiological functioning in adolescents.Translational psychiatry · 2025Article
- Associations between structural stigma and earlier pubertal timing persist for 1 year among Black girls and Latinx youth.Scientific reports · 2025Article
- Model for predicting metabolic activity in athletes based on biochemical blood test analysis.Sports medicine and health science · 2025Article
- A Comprehensive Overview of Stress, Resilience, and Neuroplasticity Mechanisms.International journal of molecular sciences · 2025Review
- Exposure to diesel-related particulate matter, cortisol stress responsivity, and depressive symptoms in adolescents.Psychoneuroendocrinology · 2025Article
- The growing interdisciplinarity of developmental psychopathology: Implications for science and training.Development and psychopathology · 2024Article
- Longitudinal analysis of cortisol changes during pubertal development in indigenous Qom girls.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Salivary uric acid dynamics are associated with stress response hormones among African Americans in an urban sample.Psychoneuroendocrinology · 2024Article
- Associations among early life adversity, sleep disturbances, and depressive symptoms in adolescent females and males: a longitudinal investigation.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Atypical regulation of the hypothalamic-pituitary-adrenal (HPA) axis is a putative mechanism underlying the association between exposure to early life stress (ELS) and the subsequent development of mental and physical health difficulties. Recent research indicates that puberty is a period of HPA-axis plasticity during which the effects of exposure to ELS on cortisol regulation may change. In particular, increases in the sex hormones that drive pubertal maturation, including dehydroepiandrosterone (DHEA) and testosterone, may be implicated in pubertal recalibration of cortisol regulation. In the current study, we examined the associations among levels of objectively-rated threat-related ELS and salivary waking cortisol, DHEA, and testosterone in a sample of 178 adolescents (55 % female) who were in early puberty at baseline (Tanner stages 1-3; mean Tanner stage[SD] = 1.93[0.64]; mean age[SD] = 11.42[1.04]) and were followed up approximately two years later (mean Tanner stage[SD] = 3.46[0.86]; mean age[SD] = 13.38[1.06]). Using multi-level modeling, we disaggregated the effects of between-individual levels and within-individual increases in pubertal stage and sex hormones on change in cortisol. Controlling for between-individual differences in average pubertal stage, the association between levels of cortisol and DHEA was more strongly positive among adolescents who evidenced greater within-individual increases in pubertal stage across time. Both higher average levels and greater within-individual increases in DHEA and testosterone were associated with increases in cortisol across time, indicating positive coupling of developmental changes in these hormones; however, coupling was attenuated in adolescents who were exposed to more severe threat-related ELS prior to puberty. These findings advance our understanding of the development of the HPA-axis and its association with childhood environmental risk during puberty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.