Evidence map›Paper›PMID 32198943›Full record

ArticleThe International journal of eating disorders2020

Medical comorbidities and endocrine dysfunction in low-weight females with avoidant/restrictive food intake disorder compared to anorexia nervosa and healthy controls.

Anna Aulinas, Dean A Marengi, Francesca Galbiati, Elisa Asanza, Meghan Slattery, Christopher J Mancuso, Olivia Wons, Nadia Micali, Elana Bern, Kamryn T Eddy and 3 more

Open access · greenAbstract read
In one paragraph

Article in The International journal of eating disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Anna AulinasNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1205-7114
Dean A MarengiNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Francesca GalbiatiNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Elisa AsanzaNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Meghan SlatteryNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Christopher J MancusoNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Olivia WonsNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Nadia MicaliDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Elana BernDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1586-0930
Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0003-2601-581X
Madhusmita MisraNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-9405-2981
Elizabeth A LawsonNeuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA.
Harvard University · USMassachusetts General Hospital · USBoston Children's Hospital · USUniversity of Geneva · CH

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN TORRIANI · 1994 to 2026
$31.6M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
The Role of Estrogen in the Neurobiology of Eating Disorders: A Study of Cognitive Flexibility and Reward in Eating DisordersR01MH116205 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, MISRA, MADHUSMITA · 2019 to 2023
$4.7M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
Neurobiology of avoidant/restrictive eating in youthK24MH120568 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2019 to 2023
$961k
NCATS NIH HHS UL1 TR000170NCATS NIH HHS UL1 TR001102NIDDK NIH HHS P30 DK040561NIMH NIH HHS K24 MH120568NIMH NIH HHS R01 MH103402NIMH NIH HHS R01 MH108595NIMH NIH HHS R01 MH116205
6 · The paper itself

Abstract

objectiveTo improve our understanding of medical complications and endocrine alterations in patients with low-weight avoidant/restrictive food intake disorder (ARFID) and how they may differ from those in anorexia nervosa (AN) and healthy controls (HC).

methodWe performed an exploratory cross-sectional study comparing low-weight females with ARFID (n = 20) with females with AN (n = 42) and HC (n = 49) with no history of an eating disorder.

resultsWe found substantial overlap in medical comorbidities and endocrine features in ARFID and AN, but with earlier onset of aberrant eating behaviors in ARFID. We also observed distinct medical and endocrine alterations in ARFID compared to AN, such as a greater prevalence of asthma, a lower number of menses missed in the preceding 9 months, higher total T3 levels, and lower total T4 : total T3 ratio; these differences persisted after adjusting for age and might reflect differences in pathophysiology, acuity of weight fluctuations, and/or nutritional composition of food consumed.

conclusionThese results highlight the need for prompt diagnosis and intensive therapeutic intervention from disease onset in ARFID.

Indexed as

Avoidant Restrictive Food Intake DisorderAdolescentAdultAnorexia NervosaCase-Control StudiesChildComorbidityCross-Sectional StudiesEndocrine System DiseasesFeeding and Eating DisordersFemaleHumansRetrospective StudiesYoung Adultanorexia nervosaavoidant/restrictive food intake disorderhormone evaluationlow weightmedical comorbidities

Identifiers

PMID32198943
PMCPMC7184800
OpenAlexW3011896067

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.