Evidence map›Paper›PMID 32198840›Full record

ArticlePM & R : the journal of injury, function, and rehabilitation2020

Development and Validation of an Electronic Medical Record Algorithm to Identify Phenotypes of Rotator Cuff Tear.

Chan Gao, Run Fan, Gregory D Ayers, Ayush Giri, Kindred Harris, Ravi Atreya, Pedro L Teixeira, Nitin B Jain

Open access · greenAbstract read
In one paragraph

Article in PM & R : the journal of injury, function, and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chan GaoDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-5222-5020
Run FanDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Gregory D AyersDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Ayush GiriDivision of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kindred HarrisDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA.
Ravi AtreyaDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Pedro L TeixeiraDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Nitin B JainDepartment of Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USUniversity of California, Los Angeles · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Building Interdisciplinary Research Careers in Women's HealthK12HD043483 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARTMANN, KATHERINE E, MAJOR, AMY S · 2002 to 2023
$10.3M
VGER, the Vanderbilt Genome-Electronic Records ProjectU01HG008672 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., RODEN, DAN M · 2015 to 2019
$5.1M
The Genetic Epidemiology of Rotator Cuff Tears: the cuffGEN Study - SupplementR01AR074989 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JAIN, NITIN B · 2020 to 2025
$3.6M
Operative versus Non-Operative Treatments for Atraumatic Rotator Cuff Tears: A Mutlicenter Randomized Controlled TrialU34AR069201 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JAIN, NITIN B · 2016 to 2017
$395k
NCATS NIH HHS No. UL1TR000445NCATS NIH HHS UL1 TR000445NHGRI NIH HHS U01 HG008672NIAMS NIH HHS R01 AR074989NIAMS NIH HHS U34 AR069201NICHD NIH HHS K12 HD043483NIH HHS U01HG008672
6 · The paper itself

Abstract

backgroundA lack of studies with large sample sizes of patients with rotator cuff tears is a barrier to performing clinical and genomic research.

objectiveTo develop and validate an electronic medical record (EMR)-based algorithm to identify individuals with and without rotator cuff tear.

designWe used a deidentified version of the EMR of more than 2 million subjects. A screening algorithm was applied to classify subjects into likely rotator cuff tear and likely normal rotator cuff groups. From these subjects, 500 likely rotator cuff tear and 500 likely normal rotator cuff were randomly chosen for algorithm development. Chart review of all 1000 subjects confirmed the true phenotype of rotator cuff tear or normal rotator cuff based on magnetic resonance imaging and operative report. An algorithm was then developed based on logistic regression and validation of the algorithm was performed.

resultsThe variables significantly predicting rotator cuff tear included the number of times a Current Procedural Terminology code related to rotator cuff procedures was used (odds ratio [OR] = 3.3; 95% confidence interval [CI]: 1.6-6.8 for ≥3 vs 0), the number of times a term related to rotator cuff lesions occurred in radiology reports (OR = 2.2; 95% CI: 1.2-4.1 for ≥1 vs 0), and the number of times a term related to rotator cuff lesions occurred in physician notes (OR = 4.5; 95% CI: 2.2-9.1 for 1 or 2 times vs 0). This phenotyping algorithm had a specificity of 0.89 (95% CI: 0.79-0.95) for rotator cuff tear, area under the curve (AUC) of 0.842, and diagnostic likelihood ratios (DLRs), DLR+ and DLR- of 5.94 (95% CI: 3.07-11.48) and 0.363 (95% CI: 0.291-0.453).

conclusionOur informatics algorithm enables identification of cohorts of individuals with and without rotator cuff tear from an EMR-based data set with moderate accuracy.

Indexed as

Rotator CuffRotator Cuff InjuriesAlgorithmsElectronic Health RecordsFemaleHumansMagnetic Resonance ImagingMalePhenotype

Identifiers

PMID32198840
PMCPMC7593991
OpenAlexW3012594527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.