ArticleJournal of neurology2020
A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.
Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Perioperative changes in neurocognitive and Alzheimer's disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance.British journal of anaesthesia · 2023Trial
- Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.Annals of clinical and translational neurology · 2022Trial
- Neuroinflammation-associated thalamocortical functional connectivity and cognition in older adults.Journal of neuroinflammation · 2026Article
- Lumbar puncture seems to be safe and practical ın oldest-old patients: a protocol from a memory center.European geriatric medicine · 2025Article
- Effects of Non-Cardiac/Non-neurologic Surgery and Anaesthesia on the CSF Proteome, and Modulation by the APOE Mimetic Peptide CN-105.medRxiv : the preprint server for health sciences · 2025Article
- Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium.medRxiv : the preprint server for health sciences · 2025Article
- Lumbar Puncture Complications: A Review of Current Literature.Current pain and headache reports · 2024Review
- Role of Blood-Brain Barrier Dysfunction in Delirium following Non-cardiac Surgery in Older Adults.Annals of neurology · 2023Article
- A Role for Blood-brain Barrier Dysfunction in Delirium following Non-Cardiac Surgery in Older adults.medRxiv : the preprint server for health sciences · 2023Article
- Neuroimaging and immunological features of neurocognitive function related to substance use in people with HIV.Journal of neurovirology · 2023Article
- Successful aging after elective surgery II: Study design and methods.Journal of the American Geriatrics Society · 2023Observational
- Conserved YKL-40 changes in mice and humans after postoperative delirium.Brain, behavior, & immunity - health · 2022Article
- Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.British journal of anaesthesia · 2021Article
- Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.Scientific reports · 2021Article
- Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.Journal of Alzheimer's disease : JAD · 2021Observational
- Factors Associated with Lumbar Puncture Participation in Alzheimer's Disease Research.Journal of Alzheimer's disease : JAD · 2020Observational
- The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.Journal of Alzheimer's disease : JAD · 2020Article
- Major Complications Associated With Cerebrospinal Fluid Collection in 11 Dogs: Clinical Presentation and Imaging Characteristics.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveLumbar punctures (LPs) are important for obtaining CSF in neurology studies but are associated with adverse events and feared by many patients. We determined adverse event rates and pain scores in patients prospectively enrolled in two cohort studies who underwent LPs using a standardized protocol and 25 g needle.
methodsEight hundred and nine LPs performed in 262 patients age ≥ 60 years in the MADCO-PC and INTUIT studies were analyzed. Medical records were monitored for LP-related adverse events, and patients were queried about subjective complaints. We analyzed adverse event rates, including headaches and pain scores.
resultsThere were 22 adverse events among 809 LPs performed, a rate of 2.72% (95% CI 1.71-4.09%). Patient hospital stay did not increase due to adverse events. Four patients (0.49%) developed a post-lumbar puncture headache (PLPH). Twelve patients (1.48%) developed nausea, vasovagal responses, or headaches that did not meet PLPH criteria. Six patients (0.74%) reported lower back pain at the LP site not associated with muscular weakness or paresthesia. The median pain score was 1 [0, 3]; the mode was 0 out of 10.
conclusionsThe LP protocol described herein may reduce adverse event rates and improve patient comfort in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.