ArticleEnvironmental science and pollution research international2020
Apoptosis and DNA damage induced by silica nanoparticles and formaldehyde in human lung epithelial cells.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 28 citations in OpenAlex.
- TPP-Based Nanovesicles Kill MDR Neuroblastoma Cells and Induce Moderate ROS Increase, While Exerting Low Toxicity Towards Primary Cell Cultures: An In Vitro Study.International journal of molecular sciences · 2025Article
- Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models.MedComm · 2023Review
- Apoptosis detection: a purpose-dependent approach selection.Cell cycle (Georgetown, Tex.) · 2021Review
- RNA oxidation in chromatin modification and DNA-damage response following exposure to formaldehyde.Scientific reports · 2020Article
- Bio-Functional Sperm Parameters: Does Age Matter?Frontiers in endocrinology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human exposure to silica nanoparticles (SNPs) and formaldehyde (FA) is increasing and this has raised some concerns over their possible toxic effects on the exposed working populations. Notwithstanding several studies in this area, the combined toxicological effects of these contaminants have not been yet studied. Therefore, this in vitro study was designed to evaluate the SNPs and FA combined toxicity on human lung epithelial cells (A549 cells). The cells were exposed to SNPs and FA separately and in combined form and the single and combined toxicity of SNPs and FA were evaluated by focusing on cellular viability, DNA damage, and apoptosis via MTT, DAPI staining, DNA ladder, and Annexin V-FITC apoptosis assays. The results showed a significant increase in cytotoxicity, DNA damage, and chromatin fragmentation and late apoptotic\necrotic rates in combined treated cells compared with SNPs and FA-treated cells (P value < 0.05). Two-factorial analysis showed an additive toxic interaction between SNPs and FA. Eventually, this can be deduced that workers exposed simultaneously to SNPs and FA may be at high risk compared with exposure to each other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.