Evidence map›Paper›PMID 32198655›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020

Sympathetic outflow to skin predicts central autonomic dysfunction in multiple system atrophy.

Kazumasa Shindo, Toko Fukao, Naofumi Kurita, Akane Satake, Mai Tsuchiya, Yuta Ichinose, Takanori Hata, Kishin Koh, Takamura Nagasaka, Yoshihisa Takiyama

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Excessive sweating associated with cervical canal stenosis confirmed by microneurography recordings.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kazumasa ShindoDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan. kshindo@yamanashi.ac.jp.
Toko FukaoDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Naofumi KuritaDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Akane SatakeDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Mai TsuchiyaDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Yuta IchinoseDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Takanori HataDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Kishin KohDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Takamura NagasakaDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
Yoshihisa TakiyamaDepartment of Neurology, University of Yamanashi, 1110 Shimokatou, Chuo City, Yamanashi, 409-3898, Japan.
University of Yamanashi · JPUniversity of Yamanashi Hospital · JP

Funding

Health Promotion Administration, Ministry of Health and Welfare (TW) JSPS KAKENHI Grant Number JP18K07495
6 · The paper itself

Abstract

backgroundTo find out the physiological method for evaluating the severity of central autonomic dysfunction, we performed detailed evaluation of cutaneous vasomotor neural function in a comparatively large sample of multiple system atrophy (MSA).

methodsWe evaluated cutaneous vasomotor neural function in 24 MSA patients. Skin sympathetic nerve activity (SSNA) and sympathetic skin response (SSR) and skin blood flow (skin vasomotor reflex [SVR]) were recorded at rest, as well as reflex changes after electrical stimulation. The parameters investigated were SSNA frequency at rest, reflex latency and amplitude of SSNA reflex bursts, absolute decrease and percent reduction of SVR, recovery time, and spontaneous SVR and SSR frequency.

resultsThere were negative correlations between resting SSNA and disease duration or the SCOPA-AUT score, but these were not significant. SSNA reflex latency displayed significant positive correlations with disease duration and SCOPA-AUT score (p < 0.001 and p < 0.01, respectively). In all five patients who underwent the same examination twice, SSNA reflex latency was significantly longer at the second examination than at the first examination (p < 0.005). A significant positive correlation was identified between recovery time of skin blood flow and SCOPA-AUT score or reflex latency (p < 0.05). Significant correlations were not observed between SCOPA-AUT score or disease duration and other parameters.

conclusionsThese results suggest that some MSA patients with a comparatively short duration of disease potentially have impaired thermoregulatory function. Measurement of sympathetic outflow to the skin is potentially a useful tool for predicting the severity of central autonomic dysfunction in MSA.

Indexed as

Multiple System AtrophyElectric StimulationHumansReflexSkinSympathetic Nervous SystemCentral autonomic dysfunctionMultiple system atrophyReflex latencySkin blood flowSkin sympathetic nerve activity

Identifiers

PMID32198655
OpenAlexW3011082523

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.