ArticleIrish journal of medical science2020
Cardioprotective properties of leptin in patients with excessive body mass.
Article in Irish journal of medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04175080 (Clinical Significance and Diagnosis of Sarcopenia in Patients With Heart Failure With Preserved Ejection Fraction), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Significance and Diagnosis of Sarcopenia in Patients With Heart Failure With Preserved Ejection Fraction
Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation Mendelian Randomization Study.Hypertension (Dallas, Tex. : 1979) · 2024Article
- The Association of Leptin with Left Ventricular Hypertrophy in End-Stage Kidney Disease Patients on Dialysis.Biomedicines · 2023Article
- Menopause and women's cardiovascular health: is it really an obvious relationship?Archives of medical science : AMS · 2023Article
- Obesity and Body Mass Components Influence Exercise Tolerance and the Course of Hypertension in Perimenopausal Women.Journal of cardiovascular development and disease · 2022Article
- Leptin and cardiovascular health in high body mass index.Irish journal of medical science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdipose tissue is producing adipokines that play different roles in the pathophysiology of cardiovascular disease.
aimsThe study aimed to assess the role of selected biomarkers in hypertensive patients with overweight and obesity compared with those with normal body-mass index (BMI).
methodsA total of 62 patients with BMI < 25 kg/m
resultsOverweight and obese patients had significantly higher concentration of leptin (34 vs 18 ng/ml; p = 0.03), ADMA (0.43 vs 0.38 μmol/l, p = 0.04), and lower concentration of adiponectin (5.3 vs 7 μg/ml, p = 0.01). The only significant difference in tonometry analysis was higher aortic pulse pressure (mmHg) in patients with BMI ≥ 25 kg/m
conclusionsLeptin concentrations were inversely proportional to LVMI and PWV in patients with BMI < 25 kg/m
trial registrationClinicaltrials.gov study ID: NCT04175080.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.