SynthesisCerebral cortex (New York, N.Y. : 1991)2020
Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of genome-wide association studies identifies ancestry-specific associations underlying circulating total tau levels.Communications biology · 2022Pooled it
- Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age.The American journal of clinical nutrition · 2022Trial
- Article
- The tangential growth of the human visual cortex and maternal smoking during pregnancy.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Reduced MOV10 reveals novel functional cortical connections in an increased fear response.bioRxiv : the preprint server for biology · 2026Article
- Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.Translational psychiatry · 2026Article
- Copy number variants and the tangential expansion of the cerebral cortex.Nature communications · 2025Article
- RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons.BMC biology · 2025Article
- Intrauterine growth and the tangential expansion of the human cerebral cortex in times of food scarcity and abundance.Nature communications · 2024Article
- Population Neuroscience: Principles and Advances.Current topics in behavioral neurosciences · 2024Review
- Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.Brain : a journal of neurology · 2023Article
- Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis.Nature communications · 2023Article
- Cortical profiles of numerous psychiatric disorders and normal development share a common pattern.Molecular psychiatry · 2023Article
- Unwinding the roles of RNA helicase MOV10.Wiley interdisciplinary reviews. RNA · 2022Review
- Editorial: Population Neuroscience of Development and Aging.Frontiers in systems neuroscience · 2022Article
- Ten years of enhancing neuro-imaging genetics through meta-analysis: An overview from the ENIGMA Genetics Working Group.Human brain mapping · 2022Review
- General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study.Frontiers in human neuroscience · 2021Article
- Clinical opportunity awaits at the intersection of genomics and brain imaging.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
70 authors.
Jean ShinThe Hospital for Sick Children, University of Toronto, Toronto, M5G 0A4 ON, M5G 0A4, Canada.
Shaojie MaDepartment of Genetics, Yale University School of Medicine, New Haven, 06510 CT, USA.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.
Yash PatelHolland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.
Daniel E VosbergHolland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.
Steven TilleyHolland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.
Gennady V RoshchupkinDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
André M M SousaDepartment of Neuroscience, Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, 06510 CT, USA.
Xueqiu JianInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, 77030 Houston, 77030 TX, USA.
Rebecca GottesmanJohns Hopkins School of Medicine, Baltimore, 21205 MD, USA.
Thomas H MosleyUniversity of Mississippi Medical Center, Jackson, 39216 MS, USA.
Myriam FornageInstitute of Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, 77030 Houston, 77030 TX, USA.
Yasaman SabaGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8036 Graz, Austria.
Lukas PirpamerClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, 8036 Graz, Austria.
Helena SchmidtGottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, 8036 Graz, Austria.
Amaia Carrion-CastilloLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6525 Nijmegen, The Netherlands.
Fabrice CrivelloGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, et Université de Bordeaux, F-33000 Bordeaux, France.
Bernard MazoyerGroupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, Centre National de la Recherche Scientifique, Commissariat à l'Energie Atomique, et Université de Bordeaux, F-33000 Bordeaux, France.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, 98101 WA, USA.
Shuo LiDepartment of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, 02118, MA, USA.
Michelle LucianoCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Sherif KaramaMontreal Neurological Institute, McGill University, H3A 2B4 Montreal, QC, Canada.
Lindsay LewisMontreal Neurological Institute, McGill University, H3A 2B4 Montreal, QC, Canada.
Mark E BastinCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Mathew A HarrisCentre for Clinical Brain Sciences, University of Edinburgh, EH8 9YL Edinburgh, UK.
Joanna M WardlawCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Ian E DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, EH8 9YL Edinburgh, UK.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany.
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04109 Leipzig, Germany.
A Veronica WitteDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Frauke BeyerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Arno VillringerDepartment of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.
Nicola J ArmstrongMathematics and Statistics, Murdoch University, 6150 Perth, WA, Australia.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
David AmesNational Ageing Research Institute, Royal Melbourne Hospital, 3052 Melbourne, VIC, Australia.
Jiyang JiangCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
John B KwokBrain and Mind Centre, The University of Sydney, 2050 Sydney, NSW, Australia.
Peter R SchofieldNeuroscience Research Australia, 2031 Sydney, NSW, Australia.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Julian N TrollorCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Margaret J WrightQueensland Brain Institute, The University of Queensland, 4072 St Lucia, QLD, Australia.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, 2052 Sydney, NSW, Australia.
Natalie TerzikhanDepartment of Epidemiology, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Tavia E EvansDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Hieab H H H AdamsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
M Arfan IkramDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Stefan FrenzelDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
Sandra van der Auwera-PalitschkaDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
Robin BülowInstitute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, 17489 Greifswald, Germany.
Hans Jörgen GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17489 Greifswald, Germany.
Christophe TzourioInserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.
Aniket MishraInserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.
Sophie MaingaultInstitut des Maladies Neurodégénratives, UMR 5293, CEA, CNRS, University of Bordeaux, Ubordeaux, F-33000 Bordeaux, France.
Stephanie DebetteInserm, Bordeaux Population Health Research Center, University of Bordeaux, Team VINTAGE, UMR 1219, F-33000 Bordeaux, France.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioural Genetics, Virginia Commonwealth University, Richmond, 23284 VA, USA.
Carol E FranzDepartment of Psychiatry, University of California, San Diego, 92093 CA, USA.
William S KremenDepartment of Psychiatry, University of California, San Diego, 92093 CA, USA.
Linda DingImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, 90033 CA, USA.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, 90033 CA, USA.
ENIGMA Consortium
Nenad SestanDepartment of Genetics, Yale University School of Medicine, New Haven, 06510 CT, USA.
Zdenka PausovaThe Hospital for Sick Children, University of Toronto, Toronto, M5G 0A4 ON, M5G 0A4, Canada.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, 02118 MA, USA.
Tomas PausHolland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, M4G 1R8 ON, Canada.
neuroCHARGE Working Group
Funding
The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0MThe VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3MGenetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8MBiotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council G0700704Medical Research Council G0701120Medical Research Council G1001245Medical Research Council MR/K026992/1Medical Research Council MR/M013111/1Medical Research Council MR/N027558/1Medical Research Council MR/R024065/1NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG064955
Abstract
We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.
Indexed as
Career ChoiceAdolescentAdultAgedAged, 80 and overAptitudeBrain Cortical ThicknessCerebral CortexFemaleForm PerceptionGene Expression Regulation, DevelopmentalGenome-Wide Association StudyHumansMaleMicrofilament ProteinsMiddle AgedDAAM1 protein, humanIGF2BP1 protein, humanMAPT protein, humanMicrofilament Proteinsrho GTP-Binding ProteinsRNA-Binding Proteinstau Proteinsbrain developmentcortical surface areacortical thicknessgenome-wide association studyoccupational aptitude
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.